Isopimarane Diterpenoids from the Rhizomes of Kaempferia marginata and Their Potential Anti-inflammatory Activities

被引：24

作者：

Chokchaisiri, Ratchanaporn ^{[1
]}

Chaichompoo, Waraluck ^{[2
,3
]}

Chunglok, Warangkana ^{[4
,5
]}

Cheenpracha, Sarot ^{[1
]}

Ganranoo, Lucksagoon ^{[1
]}

Phutthawong, Nathaporn ^{[1
]}

Bureekaew, Sareeya ^{[6
]}

Suksamrarn, Apichart ^{[2
,3
]}

机构：

[1] Univ Phayao, Sch Sci, Dept Chem, Muang 56000, Phayao, Thailand

[2] Ramkhamhang Univ, Fac Sci, Dept Chem, Bangkok 10240, Thailand

[3] Ramkhamhang Univ, Fac Sci, Ctr Excellence Innovat Chem, Bangkok 10240, Thailand

[4] Walailak Univ, Sch Allied Hlth Sci, Nakhon Si Thammarat 80161, Thailand

[5] Walailak Univ, Res Inst Hlth Sci, Nakhon Si Thammarat 80161, Thailand

[6] Vidyasirimedhi Inst Sci & Technol VISTEC, Dept Energy Sci & Engn, Wangchan 21210, Rayong, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 2020年 / 83卷 / 01期

关键词：

PIMARANE DITERPENES;

D O I：

10.1021/acs.jnatprod.9b00307

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six new isopimarane diterpenes, marginaols A-F (1-6), along with eight known compounds (7-14), were isolated from the rhizomes of Kaempferia marginata. The structures and absolute configurations of 1-6 were established on the basis of spectroscopic methods and the experimental and calculated ECD data as well as comparison with the literature values. Most of the isolated compounds were tested for their nitric oxide (NO) inhibitory effects in lipopolysaccharide-activated RAW264.7 cells. Among them, marginaol B (2) was found to reduce NO levels in murine macrophage cells with an IC50 value of 28.1 +/- 1.7 mu M.

引用

页码：14 / 19

页数：6

共 20 条

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