Molecular mechanisms of glucocorticoids action: implications for treatment of rhinosinusitis and nasal polyposis

被引：28

作者：

Grzanka, Alicja ^{[1
]}

Misiolek, Maciej ^{[2
]}

Golusinski, Wojciech ^{[3
]}

Jarzab, Jerzy ^{[1
]}

机构：

[1] Med Univ Silesia, Clin Dept Internal Dis Dermatol & Allergol, PL-41800 Katowice, Poland

[2] Med Univ Silesia, Clin Dept Laryngol, PL-41800 Katowice, Poland

[3] Poznan Univ Med Sci, Greater Poland Canc Ctr, Dept Head & Neck Surg & Laryngol Oncol, Poznan, Poland

来源：

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 2011年 / 268卷 / 02期

关键词：

Glucocorticoids; Nongenomic and genomic action; Nasal polyps; Rhinitis; FLUTICASONE PROPIONATE; IN-VITRO; RECEPTOR; RHINITIS; UPDATE; DEXAMETHASONE; MANAGEMENT; SPRAY;

D O I：

10.1007/s00405-010-1330-z

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Intra-nasal glucocorticoids are the most effective drugs available for rhinosinusitis and nasal polyposis treatment. Their effectiveness depends on many factors and not all of them have been well recognized so far. The authors present the basic information on molecular mechanisms of glucocorticoid action, direct and indirect effects of glucocorticoids on transcription of genes encoding inflammatory mediators. They focus on recently proved nongenomic mechanisms which appear quickly, from several seconds to minutes after glucocorticoid administration and discuss clinical implications resulting from this knowledge. Discovery of nongenomic glucocorticoid actions allows for better use of these drugs in clinical practice.

引用

页码：247 / 253

页数：7

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