NMR and SC-XRD analyses of a solid solution of diastereomers of microphyllane diterpenoids from Salvia hirsuta

被引:5
作者
Toscano, Ruben A. [1 ]
Cardenas, Jorge [1 ]
Ortiz-Pastrana, Naytze [2 ]
Fragoso-Serrano, Mabel [3 ]
Ortega, Alfredo [1 ]
Javier Perez-Vazquez, Francisco [4 ]
del Rosario Garcia-Pena, Maria [5 ]
Bautista, Elihu [6 ]
机构
[1] Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ, Mexico City 04510, DF, Mexico
[2] IPN, Dept Quim, Ctr Invest & Estudios Avanzados, Ave IPN 2508, Mexico City 07360, DF, Mexico
[3] Univ Nacl Autonoma Mexico, Dept Farm, Fac Quim, Ciudad Univ, Mexico City 04510, DF, Mexico
[4] Univ Autonoma San Luis Potosi, CONACYT Coordinac Innovac & Aplicac Ciencia & Tec, Ave Sierra Leona 550,Lomas 2da Secc, San Luis Potosi 78210, San Luis Potosi, Mexico
[5] Univ Nacl Autonoma Mexico, Herbario Nacl Mexico, Inst Biol, Ciudad Univ, Mexico City 04510, DF, Mexico
[6] Inst Potosino Invest Cient & Tecnol AC, CONACYT Consorcio Invest Innovac & Desarrollo Zon, Camino Presa San Jose 2055,Lomas 4ta Secc, San Luis Potosi 78216, San Luis Potosi, Mexico
关键词
Salvia hirsuta; Lamiaceae; Mycrophyllane diterpenoids; Hirsutolides; Solid solution; Diastereomers; MULTIDRUG-RESISTANCE; NEOCLERODANE DITERPENOIDS; JATROPHANE DITERPENOIDS; MODULATORS; DISCOVERY; REVERSAL; CONSTITUENTS;
D O I
10.1016/j.molstruc.2019.127409
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Phytochemical investigation of the leaves and flowers from Salvia hirsuta led to the isolation of the five microphyllane-type diterpenoids (1-5), and two flavones (6-7). Hirsutolides constituted new diterpenoids containing a 5-hydroxyfuran-2(5H)-one and were isolated as an epimeric mixture at C-3 and C-15. The structures of the isolated compounds were established through the analysis of their NMR spectroscopic and MS spectrometric data; and confirmed by single-crystal X-ray diffraction studies. Cytotoxic and MDR modulatory activities of compounds 1-5 were determined. (C) 2019 Elsevier B.V. All rights reserved.
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页数:7
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