The PI3K/Akt Pathway in Tumors of endocrine Tissues

被引：103

作者：

Robbins, Helen Louise ^{[1
]}

Hague, Angela ^{[2
]}

机构：

[1] Univ Hosp Coventry & Warwickshire, Dept Gen Surg, Coventry, W Midlands, England

[2] Univ Bristol, Sch Cellular & Mol Med, Sch Oral & Dent Sci, Bristol, Avon, England

来源：

FRONTIERS IN ENDOCRINOLOGY | 2016年 / 6卷

关键词：

thyroid tumors; parathyroid tumors; pituitary tumors; adrenocortical carcinoma; phaeochromocytoma; neuroblastoma; gastroenteropancreatic neuroendocrine tumors; Akt/PKB kinases; GROWTH-FACTOR RECEPTOR; THYROID-CANCER CELLS; MORPHOPROTEOMICS DEMONSTRATES ACTIVATION; AKT ACTIVATION; PHOSPHATIDYLINOSITOL; 3-KINASE/AKT; MAMMALIAN TARGET; MTOR PATHWAY; ADRENOCORTICAL CARCINOMA; NEUROENDOCRINE TUMORS; PITUITARY-ADENOMAS;

D O I：

10.3389/fendo.2015.00188

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a key driver in carcinogenesis. Defects in this pathway in human cancer syndromes such as Cowden's disease and Multiple Endocrine Neoplasia result in tumors of endocrine tissues, highlighting its importance in these cancer types. This review explores the growing evidence from multiple animal and in vitro models and from analysis of human tumors for the involvement of this pathway in the following: thyroid carcinoma subtypes, parathyroid carcinoma, pituitary tumors, adrenocortical carcinoma, phaeochromocytoma, neuroblastoma, and gastroenteropancreatic neuroendocrine tumors. While data are not always consistent, immunohistochemistry performed on human tumor tissue has been used alongside other techniques to demonstrate Akt overactivation. We review active Akt as a potential prognostic marker and the PI3K pathway as a therapeutic target in endocrine neoplasia.

引用

页数：22

共 190 条

[1] Inhibition of the PI3K Pathway Suppresses Hormonal Secretion and Limits Growth in Pheochromocytoma Cells [J].

Adler, Joel T. ;

Hottinger, Daniel G. ;

Kunnimalaiyaan, Muthusamy ;

Chen, Herbert .

WORLD JOURNAL OF SURGERY, 2009, 33 (11) :2452-2457

[2] Integrated Genomic Characterization of Papillary Thyroid Carcinoma [J].

Agrawal, Nishant ;

Akbani, Rehan ;

Aksoy, B. Arman ;

Ally, Adrian ;

Arachchi, Harindra ;

Asa, Sylvia L. ;

Auman, J. Todd ;

Balasundaram, Miruna ;

Balu, Saianand ;

Baylin, Stephen B. ;

Behera, Madhusmita ;

Bernard, Brady ;

Beroukhim, Rameen ;

Bishop, Justin A. ;

Black, Aaron D. ;

Bodenheimer, Tom ;

Boice, Lori ;

Bootwalla, Moiz S. ;

Bowen, Jay ;

Bowlby, Reanne ;

Bristow, Christopher A. ;

Brookens, Robin ;

Brooks, Denise ;

Bryant, Robert ;

Buda, Elizabeth ;

Butterfield, Yaron S. N. ;

Carling, Tobias ;

Carlsen, Rebecca ;

Carter, Scott L. ;

Carty, Sally E. ;

Chan, Timothy A. ;

Chen, Amy Y. ;

Cherniack, Andrew D. ;

Cheung, Dorothy ;

Chin, Lynda ;

Cho, Juok ;

Chu, Andy ;

Chuah, Eric ;

Cibulskis, Kristian ;

Ciriello, Giovanni ;

Clarke, Amanda ;

Clayman, Gary L. ;

Cope, Leslie ;

Copland, John A. ;

Covington, Kyle ;

Danilova, Ludmila ;

Davidsen, Tanja ;

Demchok, John A. ;

DiCara, Daniel ;

Dhalla, Noreen .

CELL, 2014, 159 (03) :676-690

[3] High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma [J].

Ahmed, Maqbool ;

Hussain, Azhar R. ;

Bavi, Prashant ;

Ahmed, Saeeda O. ;

AlSobhi, Saif S. ;

Al-Dayel, Fouad ;

Uddin, Shahab ;

Al-Kuraya, Khawla S. .

CARCINOGENESIS, 2014, 35 (07) :1564-1572

[4] Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells -: Protective role in apoptosis [J].

Alvarez-Tejado, M ;

Naranjo-Suárez, S ;

Jiménez, C ;

Carrera, AC ;

Landázuri, MO ;

del Peso, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (25) :22368-22374

[5] Pituitary tumors: pathophysiology, clinical manifestations and management [J].

Arafah, BM ;

Nasrallah, MP .

[6] Stability of phosphoprotein as a biological marker of tumor signaling [J].

Baker, AF ;

Dragovich, T ;

Ihle, NT ;

Williams, R ;

Fenoglio-Preiser, C ;

Powis, G .

CLINICAL CANCER RESEARCH, 2005, 11 (12) :4338-4340

[7] The genomic landscape of small intestine neuroendocrine tumors [J].

Banck, Michaela S. ;

Kanwar, Rahul ;

Kulkarni, Amit A. ;

Boora, Ganesh K. ;

Metge, Franziska ;

Kipp, Benjamin R. ;

Zhang, Lizhi ;

Thorland, Erik C. ;

Minn, Kay T. ;

Tentu, Ramesh ;

Eckloff, Bruce W. ;

Wieben, Eric D. ;

Wu, Yanhong ;

Cunningham, Julie M. ;

Nagorney, David M. ;

Gilbert, Judith A. ;

Ames, Matthew M. ;

Beutler, Andreas S. .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (06) :2502-2508

[8] Preclinical Targeting of the Type I Insulin-Like Growth Factor Receptor in Adrenocortical Carcinoma [J].

Barlaskar, Ferdous M. ;

Spalding, Aaron C. ;

Heaton, Joanne H. ;

Kuick, Rork ;

Kim, Alex C. ;

Thomas, Dafydd G. ;

Giordano, Thomas J. ;

Ben-Josef, Edgar ;

Hammer, Gary D. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2009, 94 (01) :204-212

[9] PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis [J].

Bender, A. ;

Opel, D. ;

Naumann, I. ;

Kappler, R. ;

Friedman, L. ;

von Schweinitz, D. ;

Debatin, K-M ;

Fulda, S. .

ONCOGENE, 2011, 30 (04) :494-503

[10] The two TORCs and Akt [J].

Bhaskar, Prashanth T. ;

Hay, Nissim .

DEVELOPMENTAL CELL, 2007, 12 (04) :487-502

← 1 2 3 4 5 6 7 8 9 10 →