Association of plasma trimethylamine-N-oxide levels with post-stroke cognitive impairment: a 1-year longitudinal study

被引:50
作者
Zhu, Chen [1 ]
Li, Guangzong [1 ]
Lv, Zhiyu [2 ]
Li, Jing [3 ]
Wang, Xiangming [1 ]
Kang, Jie [1 ]
Zhan, Cheng [1 ]
机构
[1] Cent Hosp Panzhihua City, Dept Neurol, . 34 Yikang St, Panzhihua, Sichuan Provinc, Peoples R China
[2] Affiliated Hosp SW Med Univ, Dept Neurol, Luzhou, Sichuan Provinc, Peoples R China
[3] Cent Hosp Panzhihua City, Dept Clin Lab, Panzhihua, Sichuan Provinc, Peoples R China
关键词
Trimethylamine-N-oxide; Post-stroke cognitive impairment; Stroke; Risk factors; MENTAL-STATE-EXAMINATION; GUT MICROBIOTA; PHOSPHATIDYLCHOLINE; METABOLISM; STROKE; DETERMINANTS;
D O I
10.1007/s10072-019-04040-w
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and aims Post-stroke cognitive impairment (PSCI) is a clinical condition arising from stroke and causes significant changes to memory, thinking, and behavior. Trimethylamine-N-oxide (TMAO), the metabolite produced by gut microbiota, has mechanistic relevance to atherosclerotic diseases. This study aimed to investigate whether an association existed between elevated plasma TMAO levels and PSCI. Methods Consecutive patients with acute ischemic stroke were prospectively enrolled during Jan. 2017 to Dec. 2017. TMAO concentration was measured within 24 h after admission. PSCI was assessed using the Mini-Mental State Examination (MMSE) score after 1 year and defined as MMSE score <= 26. Binary logistic regression analysis was used to determine the contribution of TMAO level in the prediction of PSCI. Results Of the 256 patients studied (age, 67.1 +/- 11.0 years; male, 54.3%), 86 (33.6%) patients were diagnosed as PSCI. The mean TMAO level was 5.6 +/- 2.4 mu M, with quartile level as follows: < 3.9 mu M (first quartile), 3.9-5.1 mu M (second quartile), 5.2-7.4 mu M (third quartile), and > 7.4 mu M (fourth quartile). After controlling for potential confounders, multivariable logistic analysis showed that higher level of plasma TMAO was an independent predictor for cognitive impairment in post-stroke patients (the quartile 1 was used as reference, the quartile 4 odds ratio, 3.304; 95% confidence intervals, 1.335-8.178; P = 0.010). Conclusions This study demonstrated that increasing plasma level of TMAO may be associated with PSCI.
引用
收藏
页码:57 / 63
页数:7
相关论文
共 50 条
[21]   Intra-individual variation of plasma trimethylamine-N-oxide (TMAO), betaine and choline over 1 year [J].
Kuehn, Tilman ;
Rohrmann, Sabine ;
Sookthai, Disorn ;
Johnson, Theron ;
Katzke, Verena ;
Kaaks, Rudolf ;
von Eckardstein, Arnold ;
Muller, Daniel .
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2017, 55 (02) :261-268
[22]   Gamma-glutamyl transferase levels are associated with the occurrence of post-stroke cognitive impairment: a multicenter cohort study [J].
Li, Siqi ;
Liao, Xiaoling ;
Pan, Yuesong ;
Xiang, Xianglong ;
Zhang, Yumei .
BMC NEUROLOGY, 2022, 22 (01)
[23]   Plasma exosome proteomics reveals the pathogenesis mechanism of post-stroke cognitive impairment [J].
Qi, Baoyun ;
Kong, Lingbo ;
Lai, Xinxing ;
Wang, Linshuang ;
Liu, Fei ;
Ji, Weiwei ;
Wei, Dongfeng .
AGING-US, 2023, 15 (10) :4334-4362
[24]   Prognostic Value of Plasma Trimethylamine N-Oxide Levels in Patients with Acute Ischemic Stroke [J].
Zhai, Qijin ;
Wang, Xiang ;
Chen, Chun ;
Tang, Yan ;
Wang, Yuqian ;
Tian, Jisha ;
Zhao, Ying ;
Liu, Xinfeng .
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2019, 39 (08) :1201-1206
[25]   Plasma Neurofilament Light Chain as a Predictive Biomarker for Post-stroke Cognitive Impairment: A Prospective Cohort Study [J].
Wang, Zhiqiang ;
Wang, Rongyu ;
Li, Yuxia ;
Li, Mao ;
Zhang, Yaodan ;
Jiang, Lianyan ;
Fan, Jin ;
Wang, Qingsong ;
Yang, Dongdong .
FRONTIERS IN AGING NEUROSCIENCE, 2021, 13
[26]   Investigation of serum trimethylamine-N-oxide levels in missed abortion: A prospective study [J].
Sarikaya, Sevcan ;
Korez, Muslu Kazim ;
Ovali, Fadime ;
Turgut, Esranur ;
Vatansev, Huesamettin ;
Gunenc, Oguzhan .
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2024, 165 (03) :997-1001
[27]   Guggulsterone, a farnesoid X receptor antagonist lowers plasma trimethylamine-N-oxide levels: An evidence from in vitro and in vivo studies [J].
Gautam, A. ;
Paudel, Y. N. ;
Abidin, S. A. Z. ;
Bhandari, U. .
HUMAN & EXPERIMENTAL TOXICOLOGY, 2019, 38 (03) :356-370
[28]   Plasma parameters and risk factors of patients with post-stroke cognitive impairment [J].
Wu, Ji-Xia ;
Xue, Jian ;
Zhuang, Lei ;
Liu, Chun-Feng .
ANNALS OF PALLIATIVE MEDICINE, 2020, 9 (01) :45-52
[29]   Association between Blood Pressure, Blood Pressure Variability, and Post-Stroke Cognitive Impairment [J].
Lee, Kang-Po ;
Chang, Alice Y. W. ;
Sung, Pi-Shan .
BIOMEDICINES, 2021, 9 (07)
[30]   Plasma levels of trimethylamine-N-oxide are confounded by impaired kidney function and poor metabolic control [J].
Mueller, Daniel M. ;
Allenspach, Martina ;
Othman, Alaa ;
Saely, Christoph H. ;
Muendlein, Axel ;
Vonbank, Alexander ;
Drexel, Heinz ;
von Eckardstein, Arnold .
ATHEROSCLEROSIS, 2015, 243 (02) :638-644