Hydrogen peroxide induces apoptosis through the mitochondrial pathway in rat Schwann cells

被引：32
作者：
Luo, Xinjing [1 ,2 ]
Chen, Baoguo [3 ]
Zheng, Rui [3 ]
Lin, Peng [2 ]
Li, Jicheng [1 ]
Chen, Haixiao [2 ]
机构：
[1] Zhejiang Univ, Inst Cell Biol, Hangzhou 310058, Zhejiang, Peoples R China
[2] Taizhou Hosp, Dept Orthopaed, Linhai 317000, Zhejiang, Peoples R China
[3] Taizhou Hosp, Dept Centralab, Linhai 317000, Zhejiang, Peoples R China
来源：
NEUROSCIENCE LETTERS | 2010年 / 485卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Schwann cells; Hydrogen peroxide; Apoptosis; Cytochrome c; Bax; Bcl-2; OXIDATIVE STRESS; CYTOCHROME-C; DIABETIC-NEUROPATHY; BAX TRANSLOCATION; BCL-2; FAMILY; NERVE; CYTOSOL; DEATH; DATP;
D O I：
10.1016/j.neulet.2010.08.063
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Oxidative stress is one of the several mechanisms that induces apoptosis in cells. It has been shown that hydrogen peroxide (H2O2) induces apoptosis in several kinds of cells; however, the role of H2O2 in the apoptosis of Schwann cells (SCs) is currently unclear. The objective of this study was to determine whether H2O2 is capable of inducing apoptosis in SCs and whether or not such an effect is associated with the activation of mitochondria! pathway. We demonstrated that H2O2 induces apoptosis in SCs, and is associated with increased release of cytochrome c from mitochondria and the activation of caspase-3 and -9 by up-regulation of Bax and down-regulation of Bcl-2. These results suggest a potential role for H2O2 in SC injury by triggering apoptosis via the mitochondrial pathway under oxidative stress. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：60 / 64
页数：5
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