Skin Cancer Risk Among Solid Organ Recipients: A Nationwide Cohort Study in Denmark

被引：90

作者：

Jensen, Annette Ostergaard ^{[1
,2
]}

Saerke, Claus ^{[1
]}

Farkas, Dora ^{[1
]}

Pedersen, Lars ^{[1
]}

Kragballe, Knud ^{[2
]}

Sorensen, Henrik Toft ^{[3
]}

机构：

[1] Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8200 Aarhus N, Denmark

[2] Aarhus Univ Hosp, Dept Dermatol, DK-8200 Aarhus N, Denmark

[3] Aarhus Univ Hosp, Dept Med 5, DK-8200 Aarhus N, Denmark

来源：

ACTA DERMATO-VENEREOLOGICA | 2010年 / 90卷 / 05期

关键词：

skin cancer; organ transplantation; epidemiology; standardized incidence ratio; RENAL-TRANSPLANT RECIPIENTS; IMMUNOSUPPRESSIVE THERAPY; HEART; EPIDEMIOLOGY; CYCLOSPORINE; MALIGNANCIES; KIDNEY;

D O I：

10.2340/00015555-0919

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

This study assessed the risk of skin cancer following transplantation of 4 types of solid organs, and the risk of skin cancer in patients with chronic diseases that lead to organ transplantations. A population-based cohort of 5279 Danish patients who underwent heart, lung, renal and liver transplantation, and 77,782 patients with chronic heart, lung, renal and liver diseases during 1977-2006 were included in the study. Linkage to the Danish Cancer Registry allowed complete follow-up for basal cell carcinoma, squamous cell carcinoma and malignant melanoma. Standardized incidence ratios (SIR) and 95% confidence intervals (Cl) were calculated. The SIR for squamous cell carcinoma was highest among heart (SIR = 113; 95% Cl: 74-166), then renal (SIR = 81; 95% CI: 68-96), lung (SIR = 65; 95% Cl: 28-128) and liver (SIR = 60; 95% Cl: 27-113) recipients. SIR for squamous cell carcinoma was 4.8 (95% CI: 2.2-9.0) among renal failure patients, but not greatly elevated among patients with the other chronic diseases studied. Organ transplantation is a risk factor for squamous cell carcinoma, with immunosuppressive treatments being the most likely explanation for the association.

引用

页码：474 / 479

页数：6

共 29 条

[1] Cancer risk following organ transplantation:: a nationwide cohort study in Sweden [J].

Adami, J ;

Gäbel, H ;

Lindelöf, B ;

Ekström, K ;

Rydh, B ;

Glimelius, B ;

Ekbom, A ;

Adami, HO ;

Granath, F .

BRITISH JOURNAL OF CANCER, 2003, 89 (07) :1221-1227

[2]

Andersen TF, 1999, DAN MED BULL, V46, P263

[3] The risk of skin cancer in renal transplant recipients in Queensland, Australia [J].

Bavinck, JNB ;

Hardie, DR ;

Green, A ;

Cutmore, S ;

MacNaught, A ;

OSullivan, B ;

Siskind, V ;

VanDerWoude, FJ ;

Hardie, IR .

TRANSPLANTATION, 1996, 61 (05) :715-721

[4] Cancer risk in patients on dialysis and after renal transplantation [J].

Birkeland, SA ;

Lokkegaard, H ;

Storm, HH .

LANCET, 2000, 355 (9218) :1886-1887

[5] CANCER RISK AFTER RENAL-TRANSPLANTATION IN THE NORDIC COUNTRIES, 1964-1986 [J].

BIRKELAND, SA ;

STORM, HH ;

LAMM, LU ;

BARLOW, L ;

BLOHME, I ;

FORSBERG, B ;

EKLUND, B ;

FJELDBORG, O ;

FRIEDBERG, M ;

FRODIN, L ;

GLATTRE, E ;

HALVORSEN, S ;

HOLM, NV ;

JAKOBSEN, A ;

JORGENSEN, HE ;

LADEFOGED, J ;

LINDHOLM, T ;

LUNDGREN, G ;

PUKKALA, E .

INTERNATIONAL JOURNAL OF CANCER, 1995, 60 (02) :183-189

[6]

Breslow N E, 1987, IARC Sci Publ, P1

[7] Epidemiology - When an entire country is a cohort [J].

Frank, L .

SCIENCE, 2000, 287 (5462) :2398-2399

[8] Immunosuppression and risk of non-melanoma skin cancer in renal transplant recipients [J].

Glover, MT ;

Deeks, JJ ;

Raftery, MJ ;

Cunningham, J ;

Leigh, IM .

LANCET, 1997, 349 (9049) :398-398

[9]

Harringer W, 2002, WORLD J SURG, V26, P218

[10] INCIDENCE OF SKIN-CANCER AFTER RENAL-TRANSPLANTATION IN THE NETHERLANDS [J].

HARTEVELT, MM ;

BAVINCK, JNB ;

KOOTTE, AMM ;

VERMEER, BJ ;

VANDENBROUCKE, JP .

TRANSPLANTATION, 1990, 49 (03) :506-509

← 1 2 3 →