Synthesis and spectral investigation of some methyl-substituted 3-(2-pyridyl)-2-(2-thienyl)thiazolidin-4-one derivatives

被引：3

作者：

Fidan, Ismail ^{[2
]}

Kazaz, Cavit ^{[1
]}

Sahin, Ertan ^{[1
]}

Kaban, Seniz ^{[2
]}

机构：

[1] Ataturk Univ, Fac Sci, Dept Chem, TR-25240 Erzurum, Turkey

[2] Yildiz Tekn Univ, Fac Sci & Arts, Dept Chem, TR-34220 Istanbul, Turkey

来源：

JOURNAL OF CHEMICAL RESEARCH | 2010年 / 05期

关键词：

heteroaryl-substituted thiazolidinone; configuration; diastereomer; NOE-difference; X-ray crystallography; POTENTIAL ANTITUMOR-ACTIVITY; 4-THIAZOLIDONE DERIVATIVES; ANTICONVULSANT PROPERTIES; AGENTS;

D O I：

10.3184/030823410X12746350585058

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Some heteroaryl-substituted thiazolidin-4-one derivatives have been synthesised starting from thiophenecarbox-aldehydes, 2-amino-6-methylpyridine and 2-mercaptoacetic acid. However, the use of 2-mercaptopropanoic acid gave the thiazolidinone derivatives as a mixture of cis-and trans-isomers. The configuration of both the cis-and trans-isomers has been established by NOE-difference experiments. Furthermore, the stereochemistry of one of the trans isomers was established by X-ray crystallography.

引用

页码：296 / 300

页数：5

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