Pathology of Ewing's sarcoma/PNET: Current opinion and emerging concepts

被引：75

作者：

Desai, Saral S. ^{[1
]}

Jambhekar, Nirmala A. ^{[1
]}

机构：

[1] Tata Mem Hosp, Dept Pathol, Bombay 400012, Maharashtra, India

来源：

INDIAN JOURNAL OF ORTHOPAEDICS | 2010年 / 44卷 / 04期

关键词：

Ewing's sarcoma; EWS-FLI1; translocation; pathology; PNET; ROUND-CELL TUMORS; GROWTH-FACTOR; NEUROECTODERMAL TUMOR; PROGNOSTIC-FACTORS; BINDING PROTEIN; FLI-1; PROTEIN; DNA-BINDING; GENE; FAMILY; EXPRESSION;

D O I：

10.4103/0019-5413.69304

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Ewing's sarcoma/PNET are small round cell tumors showing a varying degree of neuroectodermal differentiation. They are one of the commonest tumors of childhood and occur in bone and within soft tissues. Traditionally, light microscopy with the aid of immunohistochemical stains was suitable for diagnosis. But now translocation analyses are being used not only for the diagnosis and classification of small round cell tumors, but to ascertain their prognostic significance, detect micrometastasis, and monitor minimal residual disease, with potential for targeted therapy. This article analyzes the pathology, biology, and molecular aspects of Ewing's sarcoma/PNET and discusses their clinical and therapeutic implications.

引用

页码：363 / 368

页数：6

共 62 条

[1] PTPL1 is a direct transcriptional target of EWS-FLI1 and modulates Ewing's Sarcoma tumorigenesis [J].

Abaan, OD ;

Levenson, A ;

Khan, O ;

Furth, PA ;

Üren, A ;

Toretsky, JA .

ONCOGENE, 2005, 24 (16) :2715-2722

[2]

ANGERVALL L, 1975, CANCER, V36, P240, DOI 10.1002/1097-0142(197507)36:1<240::AID-CNCR2820360127>3.0.CO

[3]

2-H

[4] The predictive potential of molecular detection in the nonmetastatic Ewing family of tumors [J].

Avigad, S ;

Cohen, IJ ;

Zilberstein, J ;

Liberzon, E ;

Goshen, Y ;

Ash, S ;

Meller, I ;

Kollender, Y ;

Issakov, J ;

Zaizov, R ;

Yaniv, I .

CANCER, 2004, 100 (05) :1053-1058

[5] DNA-BINDING AND TRANSCRIPTIONAL ACTIVATION PROPERTIES OF THE EWS-FLI-1 FUSION PROTEIN RESULTING FROM THE T(1122) TRANSLOCATION IN EWING SARCOMA [J].

BAILLY, RA ;

BOSSELUT, R ;

ZUCMAN, J ;

CORMIER, F ;

DELATTRE, O ;

ROUSSEL, M ;

THOMAS, G ;

GHYSDAEL, J .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (05) :3230-3241

[6] ERYTHROLEUKEMIA INDUCTION BY FRIEND MURINE LEUKEMIA-VIRUS - INSERTIONAL ACTIVATION OF A NEW MEMBER OF THE ETS GENE FAMILY, FLI-1, CLOSELY LINKED TO C-ETS-1 [J].

BENDAVID, Y ;

GIDDENS, EB ;

LETWIN, K ;

BERNSTEIN, A .

GENES & DEVELOPMENT, 1991, 5 (06) :908-918

[7] Prognostic factors in Ewing's tumor of bone:: Analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study group [J].

Cotterill, SJ ;

Ahrens, S ;

Paulussen, M ;

Jürgens, HF ;

Voûte, PA ;

Gadner, H ;

Craft, AW .

JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (17) :3108-3114

[8] Analysis of the expression of cell cycle regulators in Ewing cell lines:: EWS-FLI-1 modulates p57KIP2 and c-Myc expression [J].

Dauphinot, L ;

De Oliveira, C ;

Melot, T ;

Sevenet, N ;

Thomas, V ;

Weissman, BE ;

Delattre, O .

ONCOGENE, 2001, 20 (25) :3258-3265

[9] Association of EWS-FLI1 type 1 fusion with lower proliferative rate in Ewing's sarcoma [J].

de Alava, E ;

Panizo, A ;

Antonescu, CR ;

Huvos, AG ;

Pardo-Mindán, FJ ;

Barr, FG ;

Ladanyi, M .

AMERICAN JOURNAL OF PATHOLOGY, 2000, 156 (03) :849-855

[10]

de Alava E, 2000, CANCER-AM CANCER SOC, V89, P783, DOI 10.1002/1097-0142(20000815)89:4<783::AID-CNCR10>3.0.CO

← 1 2 3 4 5 6 7 →