Hematopoietic stem cell aging: Mechanism and consequence

被引：88

作者：

Rossi, Derrick J. ^{[1
]}

Bryder, David

Weissman, Irving L.

机构：

[1] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA

[2] Stanford Univ, Stanford Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA

[3] Lund Univ, Inst Expt Med Sci, S-22184 Lund, Sweden

来源：

EXPERIMENTAL GERONTOLOGY | 2007年 / 42卷 / 05期

关键词：

stem cell; aging; side population; lymphoid; myeloid; lineage potential; leukemia;

D O I：

10.1016/j.exger.2006.11.019

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Advancing age is frequented by the onset of a variety of hematological conditions characterized by diminished homeostatic control of blood cell production. The fact that upstream hematopoietic stem and progenitor cells are obligate mediators of homeostatic control of all blood lineages, has implicated the involvement of these cells in the pathophysiology of these conditions. Indeed, evidence from our group and others has suggested that two of the most clinically significant age-associated hematological conditions, namely, the diminution of the adaptive immune system and the elevated incidence of myeloproliferative diseases, have their origin in cell autonomous changes in the functional capacity of hematopoietic stem cells. (C) 2006 Elsevier Inc. All rights reserved.

引用

页码：385 / 390

页数：6

共 24 条

[1] Upregulation of flt3 expression within the bone marrow Lin-Sca1+c-kit+ stem cell compartment is accompanied by loss of self-renewal capacity [J].

Adolfsson, J ;

Borge, OJ ;

Bryder, D ;

Theilgaard-Mönch, K ;

Åstrand-Grundström, I ;

Sitnicka, E ;

Sasaki, Y ;

Jacobsen, SEW .

IMMUNITY, 2001, 15 (04) :659-669

[2] A clonogenic common myeloid progenitor that gives rise to all myeloid lineages [J].

Akashi, K ;

Traver, D ;

Miyamoto, T ;

Weissman, IL .

NATURE, 2000, 404 (6774) :193-197

[3] Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis [J].

Akashi, K ;

He, X ;

Chen, J ;

Iwasaki, H ;

Niu, C ;

Steenhard, B ;

Zhang, JW ;

Haug, J ;

Li, LH .

BLOOD, 2003, 101 (02) :383-390

[4] Rapid lymphocyte reconstitution of unconditioned immunodeficient mice with non-self-renewing multipotent hematopoietic progenitors [J].

Bhattacharya, Deepta ;

Bryder, David ;

Rossi, Derrick J. ;

Weissman, Irving L. .

CELL CYCLE, 2006, 5 (11) :1135-1139

[5] Hematopoietic stem cells - The paradigmatic tissue-specific stem cell [J].

Bryder, David ;

Rossi, Derrick J. ;

Weissman, Irving L. .

AMERICAN JOURNAL OF PATHOLOGY, 2006, 169 (02) :338-346

[6] Class-switch recombination: Interplay of transcription, DNA deamination and DNA repair [J].

Chaudhuri, J ;

Alt, FW .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) :541-552

[7] Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells [J].

Christensen, JL ;

Weissman, IL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (25) :14541-14546

[8] Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo [J].

Goodell, MA ;

Brose, K ;

Paradis, G ;

Conner, AS ;

Mulligan, RC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (04) :1797-1806

[9] Multilineage gene expression precedes commitment in the hemopoietic system [J].

Hu, M ;

Krause, D ;

Greaves, M ;

Sharkis, S ;

Dexter, M ;

Heyworth, C ;

Enver, T .

GENES & DEVELOPMENT, 1997, 11 (06) :774-785

[10] EVIDENCE THAT HEMATOPOIETIC STEM-CELLS EXPRESS MOUSE C-KIT BUT DO NOT DEPEND ON STEEL FACTOR FOR THEIR GENERATION [J].

IKUTA, K ;

WEISSMAN, IL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (04) :1502-1506

← 1 2 3 →