Occurrence and the susceptibility to antimicrobial agents in Pseudomonas aeruginosa and Acinetobacter sp. at a tertiary hospital in southern Brazil

被引：8
作者：
Machado, Gabriele Mariani [3 ]
Lago, Aldalise [2 ]
Riccardi Fuentefria, Sergio Roberto [1 ,2 ]
Fuentefria, Daiane Bopp [1 ,2 ]
机构：
[1] Lab SANI, Serv Anal Especializadas, BR-99010001 Passo Fundo, RS, Brazil
[2] Hosp Sao Vicente de Paulo, Lab Anal Clin, Passo Fundo, RS, Brazil
[3] Univ Passo Fundo, Inst Ciencias Biol, Passo Fundo, RS, Brazil
来源：
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2011年 / 44卷 / 02期
关键词：
M beta L; Bacterial resistance; Pseudomonas aeruginosa; Acinetobacter; METALLO-BETA-LACTAMASES; RESISTANCE; INFECTION; ENZYME; CITY; GENE;
D O I：
10.1590/S0037-86822011005000015
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Introduction: The main mechanism of emerging resistance in Pseudomonas aeruginosa and Acinetobacter sp. isolates is the production of metallo-beta-lactamases (M beta Ls). M beta Ls are enzymes capable of hydrolyzing cephalosporins, penicillins and carbapenems, but not monobactams (aztreonam), which are often used as antimicrobial therapy to treat nosocomial infections. Methods: An observational descriptive and retrospective study was designed to assess the frequency of M beta Ls among strains of P. aeruginosa and Acinetobacter sp. obtained from a tertiary hospital in southern Brazil. Results: M beta L production was observed in 77.6% (n = 173/223) for P. aeruginosa isolates and 22.4% (n = 50/223) of Acinetobacter sp. isolates. The Acinetobacter sp. isolates showed 92.8% sensitivity to amikacin and P. aeruginosa isolates showed 58.9% sensitivity to aztreonam. Conclusions: The M beta L indices determined confirm the global concern with this mechanism of resistance.
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页码：168 / 172
页数：5
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