Targeted renal therapies through microbubbles and ultrasound

被引：67
|
作者：
Deelman, Leo E. [1 ]
Decleves, Anne-Emilie [2 ]
Rychak, Joshua J. [3 ]
Sharma, Kumar [2 ]
机构：
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharmacol, NL-9713 AV Groningen, Netherlands
[2] Univ Calif San Diego, Dept Med, Vet Adm San Diego Healthcare Syst, Ctr Renal Translat Med,Div Nephrol, La Jolla, CA 92093 USA
[3] Targeson Inc, La Jolla, CA USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2010年 / 62卷 / 14期
关键词：
Microbubbles; Ultrasound; Kidney; Drug delivery; Bioeffects; Contrast agents; Molecular imaging; Targeted microbubbles; ENDOTHELIAL GROWTH-FACTOR; MYOCARDIAL CONTRAST ECHOCARDIOGRAPHY; MATRIX GENE-EXPRESSION; P-SELECTIN; DIAGNOSTIC ULTRASOUND; TUMOR ANGIOGENESIS; PLASMID DNA; LOCAL-DELIVERY; BLOOD-FLOW; TGF-BETA;
D O I：
10.1016/j.addr.2010.10.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Microbubbles and ultrasound enhance the cellular uptake of drugs (including gene constructs) into the kidney. Microbubble induced modifications to the size selectivity of the filtration capacity of the kidney may enable drugs to enter previously inaccessible compartments of the kidney. So far, negative renal side-effects such as capillary bleeding have been reported only in rats, with no apparent damage in larger models such as pigs and rabbits. Although local delivery is accomplished by applying ultrasound only to the target area, efficient delivery using conventional microbubbles has depended on the combined injection of both drugs and microbubbles directly into the renal artery. Conjugation of antibodies to the shell of microbubbles allows for the specific accumulation of microbubbles in the target tissue after intravenous injection. This exciting approach opens new possibilities for both drug delivery and diagnostic ultrasound imaging in the kidney. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：1369 / 1377
页数：9
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