Molecular principles of metastasis: a hallmark of cancer revisited

被引：1581

作者：

Fares, Jawad ^{[1
,2
]}

Fares, Mohamad Y. ^{[3
,4
]}

Khachfe, Hussein H. ^{[3
,4
]}

Salhab, Hamza A. ^{[3
,4
]}

Fares, Youssef ^{[4
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Neurol Surg, Chicago, IL 60611 USA

[2] Harvard Med Sch, High Impact Canc Res Program, Boston, MA 02115 USA

[3] Amer Univ Beirut, Fac Med, Beirut, Lebanon

[4] Lebanese Univ, Neurosci Res Ctr, Fac Med Sci, Beirut, Lebanon

来源：

SIGNAL TRANSDUCTION AND TARGETED THERAPY | 2020年 / 5卷 / 01期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; HYPOXIA-INDUCIBLE FACTORS; SQUAMOUS-CELL CARCINOMA; CIRCULATING TUMOR-CELLS; STEM-LIKE CELLS; BREAST-CANCER; MATRIX METALLOPROTEINASES; PROSTATE-CANCER; LUNG METASTASIS; EXTRACELLULAR-MATRIX;

D O I：

10.1038/s41392-020-0134-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-related deaths. Yet, it remains poorly understood. The continuous evolution of cancer biology research and the emergence of new paradigms in the study of metastasis have revealed some of the molecular underpinnings of this dissemination process. The invading tumor cell, on its way to the target site, interacts with other proteins and cells. Recognition of these interactions improved the understanding of some of the biological principles of the metastatic cell that govern its mobility and plasticity. Communication with the tumor microenvironment allows invading cancer cells to overcome stromal challenges, settle, and colonize. These characteristics of cancer cells are driven by genetic and epigenetic modifications within the tumor cell itself and its microenvironment. Establishing the biological mechanisms of the metastatic process is crucial in finding open therapeutic windows for successful interventions. In this review, the authors explore the recent advancements in the field of metastasis and highlight the latest insights that contribute to shaping this hallmark of cancer.

引用

页数：17

共 303 条

[1] Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution [J].

Abbosh, Christopher ;

Birkbak, Nicolai J. ;

Wilson, Gareth A. ;

Jamal-Hanjani, Mariam ;

Constantin, Tudor ;

Salari, Raheleh ;

Le Quesne, John ;

Moore, David A. ;

Veeriah, Selvaraju ;

Rosenthal, Rachel ;

Marafioti, Teresa ;

Kirkizlar, Eser ;

Watkins, Thomas B. K. ;

McGranahan, Nicholas ;

Ward, Sophia ;

Martinson, Luke ;

Riley, Joan ;

Fraioli, Francesco ;

Al Bakir, Maise ;

Gronroos, Eva ;

Zambrana, Francisco ;

Endozo, Raymondo ;

Bi, Wenya Linda ;

Fennessy, Fiona M. ;

Sponer, Nicole ;

Johnson, Diana ;

Laycock, Joanne ;

Shafi, Seema ;

Czyzewska-Khan, Justyna ;

Rowan, Andrew ;

Chambers, Tim ;

Matthews, Nik ;

Turajlic, Samra ;

Hiley, Crispin ;

Lee, Siow Ming ;

Forster, Martin D. ;

Ahmad, Tanya ;

Falzon, Mary ;

Borg, Elaine ;

Lawrence, David ;

Hayward, Martin ;

Kolvekar, Shyam ;

Panagiotopoulos, Nikolaos ;

Janes, Sam M. ;

Thakrar, Ricky ;

Ahmed, Asia ;

Blackhall, Fiona ;

Summers, Yvonne ;

Hafez, Dina ;

Naik, Ashwini .

NATURE, 2017, 545 (7655) :446-+

[2] Determination of the Pseudoscalar Decay Constant fDs+ via Ds+ → μ+νμ [J].

Ablikim, M. ;

Achasov, M. N. ;

Ahmed, S. ;

Albrecht, M. ;

Alekseev, M. ;

Amoroso, A. ;

An, F. F. ;

An, Q. ;

Bai, Y. ;

Bakina, O. ;

Ferroli, R. Baldini ;

Ban, Y. ;

Begzsuren, K. ;

Bennett, D. W. ;

Bennett, J., V ;

Berger, N. ;

Bertani, M. ;

Bettoni, D. ;

Bianchi, F. ;

Boyko, I ;

Briere, R. A. ;

Cai, H. ;

Cai, X. ;

Cakir, O. ;

Calcaterra, A. ;

Cao, G. F. ;

Cetin, S. A. ;

Chai, J. ;

Chang, J. F. ;

Chang, W. L. ;

Chelkov, G. ;

Chen, G. ;

Chen, H. S. ;

Chen, J. C. ;

Chen, M. L. ;

Chen, P. L. ;

Chen, S. J. ;

Chen, Y. B. ;

Cibinetto, G. ;

Cossio, F. ;

Dai, H. L. ;

Dai, J. P. ;

Dbeyssi, A. ;

Dedovich, D. ;

Deng, Z. Y. ;

Denig, A. ;

Denysenko, I ;

Destefanis, M. ;

De Mori, F. ;

Ding, Y. .

PHYSICAL REVIEW LETTERS, 2019, 122 (07)

[3] Observation of the Semileptonic Decay D0 → a0(980)-e+νe and Evidence for D+ → a0(980)0e+νe [J].

Ablikim, M. ;

Achasov, M. N. ;

Ahmed, S. ;

Albrecht, M. ;

Alekseev, M. ;

Amoroso, A. ;

An, F. F. ;

An, Q. ;

Bai, Y. ;

Bakina, O. ;

Ferroli, R. Baldini ;

Ban, Y. ;

Begzsuren, K. ;

Bennett, D. W. ;

Bennett, J. V. ;

Berger, N. ;

Bertani, M. ;

Bettoni, D. ;

Bianchi, F. ;

Boger, E. ;

Boyko, I. ;

Briere, R. A. ;

Cai, H. ;

Cai, X. ;

Calcaterra, A. ;

Cao, G. F. ;

Cetin, S. A. ;

Chai, J. ;

Chang, J. F. ;

Chang, W. L. ;

Chelkov, G. ;

Chen, G. ;

Chen, H. S. ;

Chen, J. C. ;

Chen, M. L. ;

Chen, S. J. ;

Chen, X. R. ;

Chen, Y. B. ;

Cheng, W. ;

Chu, X. K. ;

Cibinetto, G. ;

Cossio, F. ;

Dai, H. L. ;

Dai, J. P. ;

Dbeyssi, A. ;

Dedovich, D. ;

Deng, Z. Y. ;

Denig, A. ;

Denysenko, I. ;

Destefanis, M. .

PHYSICAL REVIEW LETTERS, 2018, 121 (08)

[4] Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis [J].

Aceto, Nicola ;

Bardia, Aditya ;

Miyamoto, David T. ;

Donaldson, Maria C. ;

Wittner, Ben S. ;

Spencer, Joel A. ;

Yu, Min ;

Pely, Adam ;

Engstrom, Amanda ;

Zhu, Huili ;

Brannigan, Brian W. ;

Kapur, Ravi ;

Stott, Shannon L. ;

Shioda, Toshi ;

Ramaswamy, Sridhar ;

Ting, David T. ;

Lin, Charles P. ;

Toner, Mehmet ;

Haber, Daniel A. ;

Maheswaran, Shyamala .

CELL, 2014, 158 (05) :1110-1122

[5] Exosomal HIF1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes [J].

Aga, M. ;

Bentz, G. L. ;

Raffa, S. ;

Torrisi, M. R. ;

Kondo, S. ;

Wakisaka, N. ;

Yoshizaki, T. ;

Pagano, J. S. ;

Shackelford, J. .

ONCOGENE, 2014, 33 (37) :4613-4622

[6] Urokinase receptor and fibronectin regulate the ERKMAPK to p38MAPK activity ratios that determine carcinoma cell proliferation or dormancy in vivo [J].

Aguirre-Ghiso, JA ;

Liu, D ;

Mignatti, A ;

Kovalski, K ;

Ossowski, L .

MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (04) :863-879

[7]

Aguirre-Ghiso JA, 2003, CANCER RES, V63, P1684

[8] Emerging Topics on Disseminated Cancer Cell Dormancy and the Paradigm of Metastasis [J].

Aguirre-Ghiso, Julio A. ;

Sosa, Maria Soledad .

ANNUAL REVIEW OF CANCER BIOLOGY, VOL 2, 2018, 2 :377-393

[9] Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice [J].

Albrengues, Jean ;

Shields, Mario A. ;

Ng, David ;

Park, Chun Gwon ;

Ambrico, Alexandra ;

Poindexter, Morgan E. ;

Upadhyay, Priya ;

Uyeminami, Dale L. ;

Pommier, Arnaud ;

Kuttner, Victoria ;

Bruzas, Emilis ;

Maiorino, Laura ;

Bautista, Carmelita ;

Carmona, Ellese M. ;

Gimotty, Phyllis A. ;

Fearon, Douglas T. ;

Chang, Kenneth ;

Lyons, Scott K. ;

Pinkerton, Kent E. ;

Trotman, Lloyd C. ;

Goldberg, Michael S. ;

Yeh, Johannes T. -H. ;

Egeblad, Mikala .

SCIENCE, 2018, 361 (6409) :1353-+

[10] Gut microbiota modulation of chemotherapy efficacy and toxicity [J].

Alexander, James L. ;

Wilson, Ian D. ;

Teare, Julian ;

Marchesi, Julian R. ;

Nicholson, Jeremy K. ;

Kinross, James M. .

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2017, 14 (06) :356-365

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