Catalyst-Free One-Pot Four Component Synthesis of Polysubstituted Imidazoles in Neutral Ionic Liquid 1-Butyl-3-methylimidazolium Bromide

被引：168

作者：

Hasaninejad, Alireza ^{[1
]}

Zare, Abdolkarim

Shekouhy, Mohsen ^{[1
]}

Rad, Javad Ameri ^{[1
]}

机构：

[1] Persian Gulf Univ, Fac Sci, Dept Chem, Bushehr 75169, Iran

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2010年 / 12卷 / 06期

关键词：

SOLVENT-FREE SYNTHESIS; TETRASUBSTITUTED IMIDAZOLES; SUBSTITUTED IMIDAZOLES; HIGHLY-EFFICIENT; 1,2,4,5-TETRASUBSTITUTED IMIDAZOLES; CONJUGATE ADDITION; SILICA-GEL; 4-COMPONENT; REAGENT; DIHYDROXYLATION;

D O I：

10.1021/cc100097m

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A catalyst-free one-pot four component methodology for the synthesis of 1,2,4,5-substituted imidazoles under conventional heating and microwave irradiation using 1-butyl-3-methylimidazolium bromide, [Bmim]Br, as a neutral reaction media is described. A broad range of structurally diverse aldehydes (aromatic aldehydes bearing electron withdrawing and/or electron releasing groups as well as heteroaromatic aldehydes) and primary amines (aromatic and aliphatic) were applied successfully, and corresponding products were obtained in good to excellent yields without any byproduct.

引用

页码：844 / 849

页数：6

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