SARS-CoV-2-specific T cells in infection and vaccination

被引：117

作者：

Bertoletti, Antonio ^{[1
,2
]}

Le Bert, Nina ^{[1
]}

Qui, Martin ^{[1
]}

Tan, Anthony T. ^{[1
]}

机构：

[1] Duke NUS Med Sch, Programme Emerging Infect Dis, Singapore, Singapore

[2] ASTAR, Singapore Immunol Network, Singapore, Singapore

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2021年 / 18卷 / 10期

基金：

新加坡国家研究基金会; 英国医学研究理事会;

关键词：

SARS-CoV-2; Vaccines; T cells; COVID-19; COVID-19; RESPONSES; EFFICACY; IMMUNITY;

D O I：

10.1038/s41423-021-00743-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During viral infections, antibodies and T cells act together to prevent pathogen spread and remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger pathological processes characterized by localized or systemic inflammatory events. The protective and/or pathological role of virus-specific T cells in SARS-CoV-2 infection has been the focus of many studies in COVID-19 patients and in vaccinated individuals. Here, we review the works that have elucidated the function of SARS-CoV-2-specific T cells in patients and in vaccinated individuals. Understanding whether SARS-CoV-2-specific T cells are more linked to protection or pathogenesis is pivotal to define future therapeutic and prophylactic strategies to manage the current pandemic.

引用

页码：2307 / 2312

页数：6

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