Laser speckle contrast imaging of blood flow in the deep brain using microendoscopy

被引：37
作者：
Chen, Ming [1 ,2 ]
Wen, Dong [1 ,2 ]
Huang, Songlin [1 ,2 ]
Gui, Shen [1 ,2 ]
Zhang, Zhihong [1 ,2 ]
Lu, Jinling [1 ,2 ]
Li, Pengcheng [1 ,2 ,3 ]
机构：
[1] Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Britton Chance Ctr Biomed Photon, Wuhan 430074, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, MoE Key Lab Biomed Photon, Collaborat Innovat Ctr Biomed Engn, Sch Engn Sci, Wuhan 430074, Hubei, Peoples R China
[3] HUST Suzhou Inst Brainmat, Suzhou 215125, Jiangsu, Peoples R China
来源：
OPTICS LETTERS | 2018年 / 43卷 / 22期
基金：
中国国家自然科学基金;
关键词：
FLUORESCENCE MICROENDOSCOPY; MOUSE-BRAIN; MU-M; MICROSCOPY; ISCHEMIA; DYNAMICS; STROKE; TISSUE;
D O I：
10.1364/OL.43.005627
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Poor blood flow circulation can occur in the subcortical regions of the brain in many brain diseases. However, the limitations of light penetration imaging techniques hinder the detection of blood flow in deep brain tissues in vivo. Hence, in this Letter, we present a gradient index lens-based laser speckle contrast imaging system for time-lapse blood flow detection in subcortical regions of the brain. We monitored the hemodynamic changes in the thalamus of mouse models of acute hypoxia and transient middle cerebral artery occlusion as a proof of concept for practical applications. (C) 2018 Optical Society of America
引用
收藏
页码：5627 / 5630
页数：4
相关论文
共 28 条
[1]   Time-lapse imaging of disease progression in deep brain areas using fluorescence microendoscopy [J].
Barretto, Robert P. J. ;
Ko, Tony H. ;
Jung, Juergen C. ;
Wang, Tammy J. ;
Capps, George ;
Waters, Allison C. ;
Ziv, Yaniv ;
Attardo, Alessio ;
Recht, Lawrence ;
Schnitzer, Mark J. .
NATURE MEDICINE, 2011, 17 (02) :223-U120
[2]   In vivo fluorescence imaging with high-resolution microlenses [J].
Barretto, Robert P. J. ;
Messerschmidt, Bernhard ;
Schnitzer, Mark J. .
NATURE METHODS, 2009, 6 (07) :511-U61
[3]   Noninvasive, in vivo imaging of subcortical mouse brain regions with 1.7 μm optical coherence tomography [J].
Chong, Shau Poh ;
Merkle, Conrad W. ;
Cooke, Dylan F. ;
Zhang, Tingwei ;
Radhakrishnan, Harsha ;
Krubitzer, Leah ;
Srinivasan, Vivek J. .
OPTICS LETTERS, 2015, 40 (21) :4911-4914
[4]   Dynamic imaging of cerebral blood flow using laser speckle [J].
Dunn, AK ;
Bolay, T ;
Moskowitz, MA ;
Boas, DA .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2001, 21 (03) :195-201
[5]   A metabolic threshold of irreversible ischemia demonstrated by PET in a middle cerebral artery occlusion-reperfusion primate model [J].
Frykholm, P ;
Andersson, JLR ;
Valtysson, J ;
Silander, HC ;
Hillered, L ;
Persson, L ;
Olsson, Y ;
Yu, WR ;
Westerberg, G ;
Watanabe, Y ;
Långström, B ;
Enblad, P .
ACTA NEUROLOGICA SCANDINAVICA, 2000, 102 (01) :18-26
[6]   Multi-channel fiber photometry for population neuronal activity recording [J].
Guo, Qingchun ;
Zhou, Jingfeng ;
Feng, Qiru ;
Lin, Rui ;
Gong, Hui ;
Luo, Qingming ;
Zeng, Shaoqun ;
Luo, Minmin ;
Fu, Ling .
BIOMEDICAL OPTICS EXPRESS, 2015, 6 (10) :3919-3931
[7]   Cellular Level Brain Imaging in Behaving Mammals: An Engineering Approach [J].
Hamel, Elizabeth J. O. ;
Grewe, Benjamin F. ;
Parker, Jones G. ;
Schnitzer, Mark J. .
NEURON, 2015, 86 (01) :140-159
[8]   Deep tissue two-photon microscopy [J].
Helmchen, F ;
Denk, W .
NATURE METHODS, 2005, 2 (12) :932-940
[9]   Multifunctional in vivo vascular imaging using near-infrared II fluorescence [J].
Hong, Guosong ;
Lee, Jerry C. ;
Robinson, Joshua T. ;
Raaz, Uwe ;
Xie, Liming ;
Huang, Ngan F. ;
Cooke, John P. ;
Dai, Hongjie .
NATURE MEDICINE, 2012, 18 (12) :1841-+
[10]   Targeting platelets in acute experimental stroke - Impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding [J].
Kleinschnitz, Christoph ;
Pozgajova, Miroslava ;
Pham, Mirko ;
Bendszus, Martin ;
Nieswandt, Bernhard ;
Stoll, Guido .
CIRCULATION, 2007, 115 (17) :2323-2330
123