G-proteins as transducers in transmembrane signalling

被引：217

作者：

Offermanns, S ^{[1
]}

机构：

[1] Heidelberg Univ, Inst Pharmacol, D-69120 Heidelberg, Germany

来源：

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 2003年 / 83卷 / 02期

关键词：

D O I：

10.1016/S0079-6107(03)00052-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The G-protein-mediated signalling system has evolved as one of the most widely used transmembrane signalling mechanisms in mammalian organisms. All mammalian cells express G-protein-coupled receptors as well as several types of heterotrimeric G-proteins and effectors. G-protein-mediated signalling is involved in many physiological and pathological processes. This review summarizes some general aspects of G-protein-mediated signalling and focusses on recent data especially from studies in mutant mice which have elucidated some of the cellular and biological functions of heterotrimeric G-prtoteins. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：101 / 130

页数：30

共 154 条

[1] REDUCED HIPPOCAMPAL LONG-TERM POTENTIATION AND CONTEXT-SPECIFIC DEFICIT IN ASSOCIATIVE LEARNING IN MGLUR1 MUTANT MICE [J].

AIBA, A ;

CHEN, C ;

HERRUP, K ;

ROSENMUND, C ;

STEVENS, CF ;

TONEGAWA, S .

CELL, 1994, 79 (02) :365-375

[2] Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy [J].

Akhter, SA ;

Luttrell, LM ;

Rockman, HA ;

Iaccarino, G ;

Lefkowitz, RJ ;

Koch, WJ .

SCIENCE, 1998, 280 (5363) :574-577

[3] G-ALPHA-16, A G-PROTEIN ALPHA SUBUNIT SPECIFICALLY EXPRESSED IN HEMATOPOIETIC-CELLS [J].

AMATRUDA, TT ;

STEELE, DA ;

SLEPAK, VZ ;

SIMON, MI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (13) :5587-5591

[4] REGULATION OF DEACTIVATION OF PHOTORECEPTOR G-PROTEIN BY ITS TARGET ENZYME AND CGMP [J].

ARSHAVSKY, VY ;

BOWNDS, MD .

NATURE, 1992, 357 (6377) :416-417

[5] G proteins and phototransduction [J].

Arshavsky, VY ;

Lamb, TD ;

Pugh, EN .

ANNUAL REVIEW OF PHYSIOLOGY, 2002, 64 :153-187

[6] RAPID G-PROTEIN-REGULATED ACTIVATION EVENT INVOLVED IN LYMPHOCYTE BINDING TO HIGH ENDOTHELIAL VENULES [J].

BARGATZE, RF ;

BUTCHER, EC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (01) :367-372

[7] Receptor-mediated adenylyl cyclase activation through XLαs, the extra-large variant of the stimulatory G protein α-subunit [J].

Bastepe, M ;

Gunes, Y ;

Perez-Villamil, B ;

Hunzelman, J ;

Weinstein, LS ;

Jüppner, H .

MOLECULAR ENDOCRINOLOGY, 2002, 16 (08) :1912-1919

[8] Mice deficient in Golf are anosmic [J].

Belluscio, L ;

Gold, GH ;

Nemes, A ;

Axel, R .

NEURON, 1998, 20 (01) :69-81

[9] Cardiac excitation-contraction coupling [J].

Bers, DM .

NATURE, 2002, 415 (6868) :198-205

[10] PHOSPHOLIPASE C-BETA-1 IS A GTPASE-ACTIVATING PROTEIN FOR GQ/11, ITS PHYSIOLOGICAL REGULATOR [J].

BERSTEIN, G ;

BLANK, JL ;

JHON, DY ;

EXTON, JH ;

RHEE, SG ;

ROSS, EM .

CELL, 1992, 70 (03) :411-418

← 1 2 3 4 5 6 7 8 9 10 →