DrugBank 5.0: a major update to the DrugBank database for 2018

被引：5077

作者：

Wishart, David S. ^{[1
,2
,3
,4
]}

Feunang, Yannick D. ^{[1
]}

Guo, An C. ^{[1
]}

Lo, Elvis J. ^{[1
]}

Marcu, Ana ^{[1
]}

Grant, Jason R. ^{[1
]}

Sajed, Tanvir ^{[2
]}

Johnson, Daniel ^{[1
]}

Li, Carin ^{[1
]}

Sayeeda, Zinat ^{[1
]}

Assempour, Nazanin ^{[1
]}

Iynkkaran, Ithayavani ^{[1
,4
]}

Liu, Yifeng ^{[2
]}

Maciejewski, Adam ^{[1
]}

Gale, Nicola ^{[5
]}

Wilson, Alex ^{[5
]}

Chin, Lucy ^{[5
]}

Cummings, Ryan ^{[5
]}

Le, Diana ^{[5
]}

Pon, Allison ^{[1
,5
]}

Knox, Craig ^{[1
,5
]}

Wilson, Michael ^{[1
,5
]}

机构：

[1] Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada

[2] Univ Alberta, Dept Comp Sci, Edmonton, AB T6G 2E9, Canada

[3] Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2N8, Canada

[4] Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB T6G 2R3, Canada

[5] OMx Personal Hlth Analyt Inc, 301-10359 104 St NW, Edmonton, AB T5J 1B9, Canada

来源：

NUCLEIC ACIDS RESEARCH | 2018年 / 46卷 / D1期

基金：

加拿大健康研究院;

关键词：

PREDICTION; DRUGS;

D O I：

10.1093/nar/gkx1037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DrugBank (www.drugbank.ca) is a web-enabled database containing comprehensivemolecular information about drugs, their mechanisms, their interactions and their targets. First described in 2006, DrugBank has continued to evolve over the past 12 years in response to marked improvements to web standards and changing needs for drug research and development. This year's update, DrugBank 5.0, represents the most significant upgrade to the database in more than 10 years. In many cases, existing data content has grown by 100% or more over the last update. For instance, the total number of investigational drugs in the database has grown by almost 300%, the number of drug-drug interactions has grown by nearly 600% and the number of SNP-associated drug effects has grown more than 3000%. Significant improvements have been made to the quantity, quality and consistency of drug indications, drug binding data as well as drug-drug and drug-food interactions. A great deal of brand new data have also been added to DrugBank 5.0. This includes information on the influence of hundreds of drugs on metabolite levels (pharmacometabolomics), gene expression levels (pharmacotranscriptomics) and protein expression levels (pharmacoprotoemics). New data have also been added on the status of hundreds of newdrug clinical trials and existing drug repurposing trials. Many other important improvements in the content, interface and performance of the DrugBank website have been made and these should greatly enhance its ease of use, utility and potential applications in many areas of pharmacological research, pharmaceutical science and drug education.

引用

页码：D1074 / D1082

页数：9

共 22 条

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Wohlgemuth, Gert ;

Mehta, Sajjan S. ;

Mejia, Ramon F. ;

Neumann, Steffen ;

Pedrosa, Diego ;

Pluskal, Tomas ;

Schymanski, Emma L. ;

Willighagen, Egon L. ;

Wilson, Michael ;

Wishart, David S. ;

Arita, Masanori ;

Dorrestein, Pieter C. ;

Bandeira, Nuno ;

Wang, Mingxun ;

Schulze, Tobias ;

Salek, Reza M. ;

Steinbeck, Christoph ;

Nainala, Venkata Chandrasekhar ;

Mistrik, Robert ;

Nishioka, Takaaki ;

Fiehn, Oliver .

NATURE BIOTECHNOLOGY, 2016, 34 (11) :1099-1101

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