Synthesis of Oxazolidin-2-ones via a Copper(I)-Catalyzed Tandem Decarboxylative/Carboxylative Cyclization of a Propiolic Acid, a Primary Amine and an Aldehyde

被引：53

作者：

Feng, Huangdi ^{[1
,2
]}

Ermolat'ev, Denis S. ^{[1
]}

Song, Gonghua ^{[2
]}

Van der Eycken, Erik V. ^{[1
]}

机构：

[1] Katholieke Univ Leuven, LOMAC, Dept Chem, Celestijnenlaan 200F, B-3001 Louvain, Belgium

[2] E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2012年 / 354卷 / 2-3期

关键词：

carboxylative cyclization; decarboxylative coupling; oxazolidinones; three-component coupling; CARBON-DIOXIDE; OXAZOLIDINONES; ALCOHOLS; CONSTRUCTION; DERIVATIVES; CATALYSIS; FIXATION; RING;

D O I：

10.1002/adsc.201100608

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A facile approach to polysubstituted oxazolidin-2-ones is presented via a copper(I)-catalyzed tandem decarboxylative/carboxylative cyclization of a propiolic acid, a primary amine and an aldehyde (PA2-coulpling). This new multicomponent coupling constitutes an efficient methodology to provide the corresponding oxazolidin-2-ones in good yields.

引用

页码：505 / 509

页数：5

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