Heparin-coated iron oxide nanoparticles: application as a liver contrast agent, toxicity and pharmacokinetics

被引：2

作者：

Fakhardo, Anna ^{[1
,2
]}

Anastasova, Elizaveta ^{[1
]}

Makarov, Victor ^{[3
]}

Ikonnikova, Evgeniia ^{[1
]}

Kulko, Ekaterina ^{[1
]}

Agadzhanian, Nikol ^{[1
]}

Yakunina, Marina ^{[4
]}

Shkodenko, Liubov ^{[1
]}

Tsvetikova, Sofia ^{[1
]}

Toropko, Maria ^{[1
]}

Koshel, Elena ^{[1
]}

Zakharov, Mikhail ^{[5
]}

Alexandrov, Georgii ^{[5
]}

Khuttunen, Olga ^{[5
]}

Kulikov, Pavel ^{[6
]}

Burmistrov, Oleg ^{[7
]}

Vinogradov, Vladimir ^{[1
]}

Prilepskii, Artur ^{[1
]}

机构：

[1] ITMO Univ, Int Inst Solut Chem Adv Mat & Technol, Lomonosova 9, St Petersburg 197101, Russia

[2] Penn State Univ, Coll Med, 500 Univ Dr, Hershey, PA 17033 USA

[3] Granov Russian Res Ctr Radiol & Surg Technol, 70 Leningradskaya St, St Petersburg 197758, Russia

[4] Blokhin Natl Med Res Ctr Oncol, Kashirskoe Highway 23, Moscow 23115478, Russia

[5] Pharmacogen Ltd, Vet Ave 26A, St Petersburg 198215, Russia

[6] Fed Med Biol Agcy, Fed State Budgetary Inst Ctr Strateg Planning & M, Pogodinskaya St 10, Moscow 119121 1, Russia

[7] ITMO Univ, Sch Phys & Engn, St Petersburg, Russia

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2022年 / 10卷 / 38期

关键词：

MUTAGENICITY; GENOTOXICITY;

D O I：

10.1039/d2tb00759b

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The prepared heparin-coated iron oxide nanoparticles (Hep-IONPs) contrasted cholangioma tumors in the liver in T-2 MRI. The NPs were not toxic to rats and rabbits after 14 days of consecutive IV injections as observed from the monitoring of the body weight and biochemical and hematological parameters. No embryotoxic or immunotoxic side effects of the material were detected. However, we observed mutagenicity of iron oxide NPs in the Ames test and micronucleus assay. The pharmacokinetic studies showed that Hep-IONPs circulated in the blood for 14 days after IV injection. The liver iron level reached its maximum after 6 hours and slowly decreased within 30 days. Altogether, these results suggest that the synthesized Hep-IONPs are promising for use as the MRI contrast agent to identify liver malignancies.

引用

页码：7797 / 7807

页数：11

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