The inflammatory protein Pentraxin 3 in cardiovascular disease

被引：71

作者：

Fornai, Francesco ^{[1
,3
]}

Carrizzo, Albino ^{[1
]}

Forte, Maurizio ^{[1
]}

Ambrosio, Mariateresa ^{[1
]}

Damato, Antonio ^{[1
]}

Ferrucci, Michela ^{[3
]}

Biagioni, Francesca ^{[1
]}

Busceti, Carla ^{[1
]}

Puca, Annibale A. ^{[2
,4
]}

Vecchione, Carmine ^{[1
,2
]}

机构：

[1] IRCCS Neuromed, Pozzilli, IS, Italy

[2] Univ Salerno, Dept Med & Surg, Via S Allende, I-84081 Baronissi, SA, Italy

[3] Univ Pisa, Dept Translat Res & New Technol Med & Surg, Pisa, Italy

[4] IRCCS Multimed, Vasc Physiopathol Unit, Milan, Italy

来源：

IMMUNITY & AGEING | 2016年 / 13卷

关键词：

Pentraxin; 3; Acute phase protein of inflammation; Cardiovascular diseases; Myocardial infarction; Atherosclerosis; Angiogenesis; C-REACTIVE PROTEIN; NITRIC-OXIDE SYNTHASE; SMOOTH-MUSCLE-CELLS; LONG PENTRAXIN; ENDOTHELIAL DYSFUNCTION; INNATE IMMUNITY; VASCULAR INFLAMMATION; PATTERN-RECOGNITION; UNSTABLE ANGINA; HEART-FAILURE;

D O I：

10.1186/s12979-016-0080-1

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The acute phase protein Pentraxin 3 (PTX3) plays a non-redundant role as a soluble pattern recognition receptor for selected pathogens and it represents a rapid biomarker for primary local activation of innate immunity and inflammation. Recent evidence indicates that PTX3 exerts an important role in modulating the cardiovascular system in humans and experimental models. In particular, there are conflicting points concerning the effects of PTX3 in cardiovascular diseases (CVD) since several observations indicate a cardiovascular protective effect of PTX3 while others speculate that the increased plasma levels of PTX3 in subjects with CVD correlate with disease severity and with poor prognosis in elderly patients. In the present review, we discuss the multifaceted effects of PTX3 on the cardiovascular system focusing on its involvement in atherosclerosis, endothelial function, hypertension, myocardial infarction and angiogenesis. This may help to explain how the specific modulation of PTX3 such as the use of different dosing, time, and target organs could help to contain different vascular diseases. These opposite actions of PTX3 will be emphasized concerning the modulation of cardiovascular system where potential therapeutic implications of PTX3 in humans are discussed.

引用

页数：9

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