Hollow Copper Sulfide Nanosphere-Doxorubicin/Graphene Oxide Core-Shell Nanocomposite for Photothermo-chemotherapy

被引：50

作者：

Han, Lu ^{[1
]}

Hao, Ya-Nan ^{[1
]}

Wei, Xing ^{[1
]}

Chen, Xu-Wei ^{[1
]}

Shu, Yang ^{[1
]}

Wang, Jian-Hua ^{[1
]}

机构：

[1] Northeastern Univ, Coll Sci, Dept Chem, Res Ctr Analyt Sci, Box 332, Shenyang 110189, Liaoning, Peoples R China

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2017年 / 3卷 / 12期

关键词：

copper sulfide; graphene oxide; controlled drug delivery; photothermal therapy; cancer therapy; MESOPOROUS SILICA NANOPARTICLES; VIVO CANCER-THERAPY; NEAR-INFRARED LIGHT; GRAPHENE OXIDE; IN-VIVO; DRUG-DELIVERY; SYNERGISTIC THERAPY; GOLD NANODENDRITES; CARBON NANOTUBES; COMBINATION;

D O I：

10.1021/acsbiomaterials.7b00643

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A novel core-shell nanostructure, hollow copper sulfide nanosphere-doxorubicin (DOX)/graphene oxide (GO) (CuS-DOX/GO), is constructed for the purpose of controlled drug delivery and improved photothermo-chemotherapeutic effect. The CuS-DOX/GO nanocomposite is configured by employing dual photothermal agents, where the core, hollow CuS nanoparticle, acts as delivery-carrier for doxorubicin, and the shell, PEGylated GO nanosheet, prohibits leakage of the drug. DOX can be efficiently loaded onto the hollow CuS nanoparticles, and its subsequent release from CuS-DOX/GO nanocomposite is triggered in a pH- and near-infrared light-dependent manner. Moreover, integration of the two photothermal agents significantly improves the photothermal performance of this system. Ultimately, the combination of phototherapy and chemotherapy based on this system results in a much higher HeLa cell killing efficacy with respect to that for a single chemotherapy mode, as demonstrated by in vitro cytotoxicity tests.

引用

页码：3230 / 3235

页数：6

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