Notch signaling in leukemia

被引：208

作者：

Aster, Jon C. ^{[1
]}

Pear, Warren S. ^{[2
]}

Blacklow, Stephen C. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[2] Univ Penn, Abramson Family Canc Res Inst, Inst Med & Engn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE | 2008年 / 3卷

关键词：

regulated intramembranous proteolysis; transcriptional activation; expression profiling; mouse modeling; targeted therapy;

D O I：

10.1146/annurev.pathmechdis.3.121806.154300

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Recent discoveries indicate that gain-of-function mutations in the Notch1 receptor are very common in human T cell acute lymphoblastic leukemia/lymphoma. This review discusses what these mutations have taught us about normal and pathophysiologic Notch1 signaling, and how these insights may lead to new targeted therapies for patients with this aggressive form of cancer.

引用

页码：587 / 613

页数：27

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