Brain H+/CO2 sensing and control by glial cells

被引:21
作者
Gourine, Alexander, V [1 ]
Dale, Nicholas [2 ]
机构
[1] UCL, Dept Neurosci Physiol & Pharmacol, Ctr Cardiovasc & Metab Neurosci, London WC1E 6BT, England
[2] Univ Warwick, Sch Life Sci, Coventry, W Midlands, England
基金
英国惠康基金; 英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词
acid-base balance; carbon dioxide; pH; respiratory circuits; NUCLEUS-TRACTUS-SOLITARII; GAP-JUNCTIONS; CENTRAL CHEMORECEPTION; PURINERGIC MODULATION; VENTROLATERAL MEDULLA; RESPIRATORY NETWORKS; VENTILATORY RESPONSE; COTRANSPORTER NBCE1; ADENOSINE RELEASE; CRYSTAL-STRUCTURE;
D O I
10.1002/glia.24152
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Maintenance of constant brain pH is critically important to support the activity of individual neurons, effective communication within the neuronal circuits, and, thus, efficient processing of information by the brain. This review article focuses on how glial cells detect and respond to changes in brain tissue pH and concentration of CO2, and then trigger systemic and local adaptive mechanisms that ensure a stable milieu for the operation of brain circuits. We give a detailed account of the cellular and molecular mechanisms underlying sensitivity of glial cells to H+ and CO2 and discuss the role of glial chemosensitivity and signaling in operation of three key mechanisms that work in concert to keep the brain pH constant. We discuss evidence suggesting that astrocytes and marginal glial cells of the brainstem are critically important for central respiratory CO2 chemoreception-a fundamental physiological mechanism that regulates breathing in accord with changes in blood and brain pH and partial pressure of CO2 in order to maintain systemic pH homeostasis. We review evidence suggesting that astrocytes are also responsible for the maintenance of local brain tissue extracellular pH in conditions of variable acid loads associated with changes in the neuronal activity and metabolism, and discuss potential role of these glial cells in mediating the effects of CO2 on cerebral vasculature.
引用
收藏
页码:1520 / 1535
页数:16
相关论文
共 50 条
[41]   Thermodynamic analysis of methane reforming with CO2, CO2 + H2O, CO2 + O2 and CO2 + air for hydrogen and synthesis gas production [J].
Freitas, Antonio C. D. ;
Guirardello, Reginaldo .
JOURNAL OF CO2 UTILIZATION, 2014, 7 :30-38
[42]   Adsorption of CO2 and coadsorption of H and CO2 on potassium-promoted Cu(115) [J].
Onsgaard, J ;
Hoffmann, SV ;
Moller, P ;
Godowski, PJ ;
Wagner, JB ;
Paolucci, G ;
Baraldi, A ;
Comelli, G ;
Groso, A .
CHEMPHYSCHEM, 2003, 4 (05) :466-473
[43]   Effect of H2O and CO2 on NOx emission control for lean-burn engines by electrochemical-catalytic cells [J].
Huang, Ta-Jen ;
Wu, Chung-Ying ;
Chiang, De-Yi .
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 2013, 19 (03) :1024-1030
[44]   Phase equilibria of (CO2 + H2O + NaCl) and (CO2 + H2O + KCl): Measurements and modeling [J].
Hou, Shu-Xin ;
Maitland, Geoffrey C. ;
Trusler, J. P. Martin .
JOURNAL OF SUPERCRITICAL FLUIDS, 2013, 78 :78-88
[45]   Full-color CO2 gas sensing by an inverse opal photonic hydrogel [J].
Hong, Wei ;
Chen, Yuan ;
Feng, Xue ;
Yan, Yang ;
Hu, Xiaobin ;
Zhao, Binyuan ;
Zhang, Fan ;
Zhang, Di ;
Xu, Zhou ;
Lai, Yijian .
CHEMICAL COMMUNICATIONS, 2013, 49 (74) :8229-8231
[46]   CO2 induced pHi changes in the brain of polar fish: a TauCEST application [J].
Wermter, Felizitas C. ;
Maus, Bastian ;
Poertner, Hans-O. ;
Dreher, Wolfgang ;
Bock, Christian .
NMR IN BIOMEDICINE, 2018, 31 (08)
[47]   CO2 rebreathing: an undergraduate laboratory to study the chemical control of breathing [J].
Domnik, N. J. ;
Turcotte, S. E. ;
Yuen, N. Y. ;
Iscoe, S. ;
Fisher, J. T. .
ADVANCES IN PHYSIOLOGY EDUCATION, 2013, 37 (04) :361-369
[48]   REACTION OF CO2 AND H2 IN THE PRESENCE OF CO AND NI CATALYSTS [J].
LAPIDUS, AL ;
KRYLOVA, AY ;
KIM, AO ;
PAUSHKIN, YM .
RUSSIAN CHEMICAL BULLETIN, 1993, 42 (03) :434-436
[49]   CO2 = CO + O: Redox-Neutral Lactamization and Lactonization of C-H Bonds with CO2 [J].
Zhang, Zhen ;
Ju, Tao ;
Ye, Jian-Heng ;
Yu, Da-Gang .
SYNLETT, 2017, 28 (07) :741-750
[50]   Control of CO2 in a naturally ventilated classroom [J].
Griffiths, M. ;
Eftekhari, M. .
ENERGY AND BUILDINGS, 2008, 40 (04) :556-560