Diazotized Curcumin Containing Sulfonamides: Synthesis, Characterization and Antibacterial Activities

被引：0

作者：

Ahmed, Mahmood ^{[1
]}

Qadir, Muhammad A. ^{[1
]}

Shafiq, Muhammad I. ^{[2
]}

机构：

[1] Univ Punjab, Inst Chem, Lahore 54590, Pakistan

[2] Univ Punjab, Inst Biochem & Biotechnol, Lahore 54590, Pakistan

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2017年 / 36卷 / 09期

关键词：

bacterial strains; curcumin; diazotization; sulfonamides; BIOLOGICAL EVALUATION; ANTIOXIDANT ACTIVITY; METAL-COMPLEXES; DERIVATIVES; ANTIFUNGAL; INHIBITORS; ANALOGS; DESIGN;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Curcumin is a multi-functional pharmacologically safe natural agent with proven cytoprotective effects to healthy human cells. In this study, a new series of sulfonamides with curcumin scaffold were synthesized, characterized and investigated for their antibacterial activities. IR, H-1 NMR spectral data and elemental analysis were performed to elucidate the structure of newly synthesized compounds. Compound 1 with isoxazole moiety was most susceptible to all bacterial strains under investigation particularly to Gram (+) Staphylococcus aureus and activity index was 56.2 % with inhibition zone diameter 18.7 mm when compared with ciprofloxacin.

引用

页码：1789 / 1795

页数：7

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