Diazotized Curcumin Containing Sulfonamides: Synthesis, Characterization and Antibacterial Activities

Curcumin is a multi-functional pharmacologically safe natural agent with proven cytoprotective effects to healthy human cells. In this study, a new series of sulfonamides with curcumin scaffold were synthesized, characterized and investigated for their antibacterial activities. IR, H-1 NMR spectral data and elemental analysis were performed to elucidate the structure of newly synthesized compounds. Compound 1 with isoxazole moiety was most susceptible to all bacterial strains under investigation particularly to Gram (+) Staphylococcus aureus and activity index was 56.2 % with inhibition zone diameter 18.7 mm when compared with ciprofloxacin.