'Haptoglobin concentrations in preterm and term newborns'

被引：28

作者：

Chavez-Bueno, S. ^{[1
]}

Beasley, J. A. ^{[1
]}

Goldbeck, J. M. ^{[1
]}

Bright, B. C. ^{[1
,3
]}

Morton, D. J. ^{[1
,2
]}

Whitby, P. W. ^{[1
,2
]}

Stull, T. L. ^{[1
,2
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Sect Pediat Infect Dis, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol & Immunol, Oklahoma City, OK 73104 USA

[3] Univ Oklahoma, Hlth Sci Ctr, Dept Biostat & Epidemiol, Oklahoma City, OK 73104 USA

来源：

JOURNAL OF PERINATOLOGY | 2011年 / 31卷 / 07期

关键词：

neonatal sepsis; inflammation; diagnosis; ACUTE-PHASE PROTEINS; HEMOGLOBIN SCAVENGER RECEPTOR; NEONATAL SEPSIS; SERUM CONCENTRATIONS; EARLY-DIAGNOSIS; CORD BLOOD; INFANTS; PLASMA; INTERLEUKIN-6; CYTOKINES;

D O I：

10.1038/jp.2010.197

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To measure systemic haptoglobin (HPT) concentrations from birth in preterm (PT) and T newborns. To compare HPT in newborns without hemolysis or infection with values in bacteremic newborns. Study Design: HPT was measured using enzyme-linked immunosorbent assay in 30 PT and 28 T newborns without hemolysis or infection at birth (cord blood), on days of life 2 to 4, and at 1 to 2 weeks of life. Concentrations were measured in eight additional newborns with bacteremia. Wilcoxon-Mann-Whitney test was used for comparisons. Result: HPT concentrations were consistently measurable from birth in PT and T neonates. Values were significantly greater in 2- to 4-day-old PT and T newborns than in newborns at birth (P<0.01). Bacteremic newborns had higher HPT concentrations than newborns without infection (P=0.033). Conclusion: HPT is detectable from birth in PT and T newborns. HPT concentrations increase in bacteremic newborns. HPT levels may have clinical utility in the evaluation of neonatal sepsis. Journal of Perinatology (2011) 31, 500-503; doi:10.1038/jp.2010.197; published online 20 January 2011

引用

页码：500 / 503

页数：4

共 30 条

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