4-Chlorobenzaldehyde (1-isobutyl-1H-imidazo[4,5-c]quinolin-4-yl)hydrazone monohydrate

被引：7

作者：

Loh, Wan-Sin ^{[1
]}

Fun, Hoong-Kun ^{[1
]}

Kayarmar, Reshma ^{[2
]}

Viveka, S. ^{[2
]}

Nagaraja, G. K. ^{[2
]}

机构：

[1] Univ Sains Malaysia, Sch Phys, Xray Crystallog Unit, Usm 11800, Penang, Malaysia

[2] Mangalore Univ, Dept Chem, Mangalore, Karnataka, India

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2011年 / 67卷

关键词：

BIOLOGICAL EVALUATION; ANTITUMOR AGENTS; X-RAY; DIFFRACTION;

D O I：

10.1107/S1600536811001577

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

In the title compound, C21H20ClN5 center dot H2O, the 1H-imidazo[4,5-c]quinoline ring is approximately planar, with a maximum deviation of 0.0795 (7) angstrom, and it forms a dihedral angle of 7.65 (3)degrees with the chlorophenyl ring. In the crystal, the components are linked into chains along the a axis via intermolecular N-H center dot center dot center dot O, O-H center dot center dot center dot N and C-H center dot center dot center dot O hydrogen bonds. One of the H atoms of the water molecule is disordered over two positions with a site-occupancy ratio of 0.80 (4):0.20 (4).

引用

页码：O407 / U1012

页数：12

共 13 条

[1] TABLES OF BOND LENGTHS DETERMINED BY X-RAY AND NEUTRON-DIFFRACTION .1. BOND LENGTHS IN ORGANIC-COMPOUNDS [J].

ALLEN, FH ;

KENNARD, O ;

WATSON, DG ;

BRAMMER, L ;

ORPEN, AG ;

TAYLOR, R .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1987, (12) :S1-S19

[2]

[Anonymous], 2009, APEX2 SAINT SADABS

[3] POTENTIAL ANTITUMOR AGENTS .57. 2-PHENYLQUINOLINE-8-CARBOXAMIDES AS MINIMAL DNA-INTERCALATING ANTITUMOR AGENTS WITH INVIVO SOLID TUMOR-ACTIVITY [J].

ATWELL, GJ ;

BAGULEY, BC ;

DENNY, WA .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (02) :396-401

[4]

COLINS CH, 1970, MICROBIOLOGICAL METH

[5] A NITROGEN-GAS-STREAM CRYOSTAT FOR GENERAL X-RAY-DIFFRACTION STUDIES [J].

COSIER, J ;

GLAZER, AM .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1986, 19 (02) :105-107

[6] Synthesis and biological evaluation of certain α,β-unsaturated ketones and their corresponding fused pyridines as antiviral and cytotoxic agents [J].

El-Subbagh, HI ;

Abu-Zaid, SM ;

Mahran, MA ;

Badria, FA ;

Al-Obaid, AM .

JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (15) :2915-2921

[7] SYNTHESIS AND CYTOTOXICITY OF 1,6,7,8-SUBSTITUTED 2-(4'SUBSTITUTED PHENYL)-4-QUINOLONES AND RELATED-COMPOUNDS - IDENTIFICATION AS ANTIMITOTIC AGENTS INTERACTING WITH TUBULIN [J].

KUO, SC ;

LEE, HZ ;

JUANG, JP ;

LIN, YT ;

WU, TS ;

CHANG, JJ ;

LEDNICER, D ;

PAULL, KD ;

LIN, CM ;

HAMEL, E ;

LEE, KH .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (09) :1146-1156

[8] 1-Isobutyl-N,N-dimethyl-1H-imidazo[4,5-c]quinolin-4-amine [J].

Loh, Wan-Sin ;

Fun, Hoong-Kun ;

Kayarmar, Reshma ;

Viveka, S. ;

Nagaraja, G. K. .

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 :O405-U990

[9] 4-Hydrazinyl-1-isobutyl-1H-imidazo[4,5-c]quinoline [J].

Loh, Wan-Sin ;

Fun, Hoong-Kun ;

Kayarmar, Reshma ;

Viveka, S. ;

Nagaraja, G. K. .

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 :O406-U1000

[10]

OCHIAI E, 1977, BIOINORGANIC CHEM

← 1 2 →