The antioxidant compounds isolated from the fruits of chinese wild raspberry Rubus Chingii Hu

被引：24

作者：

He, Yangqing ^{[1
]}

Jin, Shanshan ^{[1
]}

Ma, Zhanying ^{[2
]}

Zhao, Jie ^{[1
]}

Yang, Qian ^{[1
]}

Zhang, Qian ^{[1
]}

Zhao, Yingjuan ^{[1
]}

Yao, Binghua ^{[1
]}

机构：

[1] Xian Univ Technol, Dept Appl Chem, Xian, Peoples R China

[2] Xianyang Normal Univ, Dept Chem, Xianyang, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2020年 / 34卷 / 06期

关键词：

Rosaceae; Rubus chingji Hu; terpenes; ent-kaurane diterpene; antioxidant activity; cytotoxicity; COMPONENTS; GLYCOSIDES;

D O I：

10.1080/14786419.2018.1504046

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Raspberry, the fruit of Rubus Chingji Hu, is a widely distributed economic staple food in China. It has long been used as a traditional medicine in mainland China to treat kidney enuresis, nocturnal emission and premature ejaculation in clinic. In this paper, six known compounds (1 - 6) were purified from the fruits of Rubus chingji. Their structures were elucidated as (16 alpha)-16,17-dihydroxy-ent-kauran-2-one17-O-beta-D-glucopyranoside (1), (16R) -16,17-dihydroxy-ent-kaurane-2-one (2), 3,3 '-di-O-methylellagic acid 4-(5 ''-acetyl)-alpha-L-arabinofuranoside (3), quercilicoside A (4), esculetine (5) and ethyl-beta-D-glucoside (6). All the compounds were isolated from Rubus Chingji Hu for the first time. Compounds 3 and 5 shown distinctive free radical scavenging activities in DPPH and FRAP assays. In addition, no cytotoxicity was observed for compounds 3 and 5 against different cancer cells, suggesting that they might be useful as potential antioxidant agents against various reactive oxygen species. [GRAPHICS] .

引用

页码：872 / 875

页数：4

共 8 条

[1] Pasteurization of blackberry juice preserves polyphenol-dependent inhibition for lipid peroxidation and intracellular radicals [J].

Azofeifa, Gabriela ;

Quesada, Silvia ;

Perez, Ana M. ;

Vaillant, Fabrice ;

Michel, Alain .

JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 2015, 42 :56-62

[2] Antioxidant capacity and bioactive compounds of four Brazilian native fruits [J].

Denardin, Cristiane C. ;

Hirsch, Gabriela E. ;

da Rocha, Ricardo F. ;

Vizzotto, Marcia ;

Henriques, Amelia T. ;

Moreira, Jose C. F. ;

Guma, Fatima T. C. R. ;

Emanuelli, Tatiana .

JOURNAL OF FOOD AND DRUG ANALYSIS, 2015, 23 (03) :387-398

[3] Extracts and Constituents of Rubus chingii with 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Free Radical Scavenging Activity [J].

Ding, Hsiou-Yu .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2011, 12 (06) :3941-3949

[4] Chemical composition and antioxidant activity of Chinese wild raspberry (Rubus hirsutus Thunb.) [J].

Fu, Yu ;

Zhou, Xiaozhou ;

Chen, Shiguo ;

Sun, Yujing ;

Shen, Yan ;

Ye, Xingqian .

LWT-FOOD SCIENCE AND TECHNOLOGY, 2015, 60 (02) :1262-1268

[5] Antithrombotic activity of fractions and components obtained from raspberry leaves (Rubus chingii) [J].

Han, Na ;

Gu, Yuhong ;

Ye, Chun ;

Cao, Yan ;

Liu, Zhihui ;

Yin, Jun .

FOOD CHEMISTRY, 2012, 132 (01) :181-185

[6] Anti-Osteoporotic Components of Rubus chingii [J].

Liang, Wen-Qing ;

Xu, Guo-Jian ;

Weng, Dong ;

Gao, Bo ;

Zheng, Xing-Feng ;

Qian, Yu .

CHEMISTRY OF NATURAL COMPOUNDS, 2015, 51 (01) :47-49

[7] Flavonoid glycosides from Rubus chingii Hu fruits display anti-inflammatory activity through suppressing MAPKs activation in macrophages [J].

Zhang, Tian-Tian ;

Wang, Min ;

Yang, Li ;

Jiang, Jian-Guo ;

Zhao, Jing-Wen ;

Zhu, Wei .

JOURNAL OF FUNCTIONAL FOODS, 2015, 18 :235-243

[8] Three new labdane-type diterpene glycosides from fruits of Rubus chingii and their cytotoxic activities against five humor cell lines [J].

Zhong, Ruijian ;

Guo, Qing ;

Zhou, Guoping ;

Fu, Huizheng ;

Wan, Kaihua .

FITOTERAPIA, 2015, 102 :23-26

← 1 →