Synthesis and characterization of new quinazolinylmethylsulfanylpyridines, quinazolinylthieno[2,3-b]pyridines and pyrido[3",2":4′,5′] thieno[3′,2′:4,5]pyrimido[6,1-b]quinazolines

被引：0

作者：

El-Ossaily, Yasser A. ^{[1
]}

Al-Taifi, Elham A. ^{[2
]}

Bakhite, Etify A. ^{[3
]}

Marae, Islam S. ^{[3
]}

Zaki, Remon M. ^{[3
]}

机构：

[1] Jouf Univ, Coll Sci, Chem Dept, Sakaka 2014, Saudi Arabia

[2] Sanaa Univ, Fac Sci, Chem Dept, Sanaa, Yemen

[3] Assiut Univ, Fac Sci, Chem Dept, Assiut, Egypt

来源：

ARKIVOC | 2019年

关键词：

Thienopyridines; pyridothienopyrimidines; pyridothienotriazine; quinazolines; pyridothienopyrimido[6,1-b]quinazolines; DERIVATIVES; PYRIDOTHIENOPYRIMIDINES; THIENOPYRIDINES; AGENTS;

D O I：

10.24820/ark.5550190.p011.094

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of 2-chloromethylquinazoline-4(3H)-one with some 3-cyanopyridine-2(1H)-thiones gave the corresponding thioethers which upon treatment with appropriate base, underwent intramolecular ThorpeZeigler reaction affording the isomeric 3-amino-2-(3,4-dihydro-4-oxo-2-quinazolinyl)thieno[2,3-b]pyridines. In contrast, the reaction of 2-chloromethylquinazoline-4(3H)-one with 3-cyanoquinoline-(1H)-thione gave 3amino-2-(3,4-dihydro-4-oxo-2-quinazolinyl)thieno[2,3-b]quinoline directly. Reaction of the resulting aminothienopyridines/quinoline with some reagents namely; acetic anhydride, triethyl orthoformate and/ or nitrous acid were carried out and their products were identified. [GRAPHICS] .

引用

页码：446 / 458

页数：13

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