Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index

被引：110

作者：

Young, Alexander I. ^{[1
]}

Wauthier, Fabian ^{[1
,2
]}

Donnelly, Peter ^{[1
,2
]}

机构：

[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, Oxon, England

[2] Univ Oxford, Dept Stat, 24-29 St Giles, Oxford OX1 3LB, England

来源：

NATURE COMMUNICATIONS | 2016年 / 7卷

基金：

英国惠康基金;

关键词：

OBESITY-ASSOCIATED GENE; PHYSICAL-ACTIVITY; RS9939609; POLYMORPHISM; FAT MASS; ALCOHOL-CONSUMPTION; ASSOCIATION; RISK; GENOTYPE; WOMEN;

D O I：

10.1038/ncomms12724

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Genetic studies have shown that obesity risk is heritable and that, of the many common variants now associated with body mass index, those in an intron of the fat mass and obesity-associated (FTO) gene have the largest effect. The size of the UK Biobank, and its joint measurement of genetic, anthropometric and lifestyle variables, offers an unprecedented opportunity to assess gene-by-environment interactions in a way that accounts for the dependence between different factors. We jointly examine the evidence for interactions between FTO (rs1421085) and various lifestyle and environmental factors. We report interactions between the FTO variant and each of: frequency of alcohol consumption (P = 3.0 x 10(-4)); deviations from mean sleep duration (P = 8.0 x 10(-4)); overall diet (P = 5.0 x 10(-6)), including added salt (P = 1.2 x 10(-3)); and physical activity (P = 3.1 x 10(-4)).

引用

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