BK virus encephalitis with thrombotic microangiopathy in an allogeneic hematopoietic stem cell transplant recipient

被引：32

作者：

Lopes da Silva, R. ^{[1
,2
]}

Ferreira, I. ^{[1
]}

Teixeira, G. ^{[1
]}

Cordeiro, D. ^{[3
]}

Mafra, M. ^{[4
]}

Costa, I. ^{[5
]}

Bravo Marques, J. M. ^{[5
]}

Abecasis, M. ^{[1
]}

机构：

[1] Inst Portugues Oncol Lisboa, Serv Transplantacao Progenitores Hematopoiet, P-1070 Lisbon, Portugal

[2] Hosp Santo Antonio dos Capuchos CHLC, Serv Hematol, Lisbon, Portugal

[3] Inst Nacl Saude Dr Ricardo Jorge, Lisbon, Portugal

[4] Inst Portugues Oncol Lisboa, Serv Anat Patol, P-1070 Lisbon, Portugal

[5] Inst Portugues Oncol Lisboa, Serv Neurol, P-1070 Lisbon, Portugal

来源：

TRANSPLANT INFECTIOUS DISEASE | 2011年 / 13卷 / 02期

关键词：

allogeneic hematopoietic stem cell transplant; immunosuppression; BK virus encephalitis; thrombotic microangiopathy; BONE-MARROW-TRANSPLANTATION; HUMAN-IMMUNODEFICIENCY-VIRUS; RENAL-ALLOGRAFT RECIPIENTS; HEMOLYTIC-UREMIC SYNDROME; THROMBOCYTOPENIC PURPURA; POLYOMAVIRUS-BK; HUMAN HERPESVIRUS-6; JC INFECTION; CYTOMEGALOVIRUS; PATIENT;

D O I：

10.1111/j.1399-3062.2010.00581.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

P>BK virus (BKV) infection occurs most often in immunocompromised hosts, in the setting of renal or bone marrow transplantation. Hemorrhagic cystitis is the commonest manifestation but in recent years infections in other organ systems have been reported. We report an unusual case of biopsy-proven BKV encephalitis in a hematopoietic stem cell transplant patient who subsequently developed thrombotic microangiopathy. As far as we know, this is the first report of such an association in a transplant patient.

引用

页码：161 / 167

页数：7

共 48 条

[1] Viruses in posttransplant thrombotic microangiopathy [J].

Afzal, F ;

Budisavljevic, MN ;

Rajagopalan, PR ;

Baliga, PK .

TRANSPLANTATION, 2001, 72 (04) :750-750

[2] HIV associated thrombotic microangiopathy [J].

Ahmed, S ;

Siddiqui, RK ;

Siddiqui, AK ;

Zaidi, SA ;

Cervia, J .

POSTGRADUATE MEDICAL JOURNAL, 2002, 78 (923) :520-525

[3] Current understanding of the pathophysiology of thrombotic thrombocytopenic purpura [J].

Allford, SL ;

Machin, SJ .

JOURNAL OF CLINICAL PATHOLOGY, 2000, 53 (07) :497-501

[4] Viruses and thrombotic microangiopathy [J].

Baid, S ;

Pascual, M ;

Cosimi, AB ;

Chung, RT ;

Colvin, RB ;

Tolkoff-Rubin, N .

TRANSPLANTATION, 1999, 68 (05) :710-711

[5]

Baid S, 1999, J AM SOC NEPHROL, V10, P146

[6] HIV-associated thrombotic microangiopathy in the era of highly active antiretroviral therapy: An observational study [J].

Becker, S ;

Fusco, G ;

Fusco, J ;

Balu, R ;

Gangjee, S ;

Brennan, C ;

Feinberg, J .

CLINICAL INFECTIOUS DISEASES, 2004, 39 :S267-S275

[7] BK virus encephalitis in an allogeneic hematopoietic stem cell recipient [J].

Behre, G. ;

Becker, M. ;

Christopeit, M. .

BONE MARROW TRANSPLANTATION, 2008, 42 (07) :499-499

[8] BK virus DNA in CSF of immunocompetent and immunocompromised patients [J].

Behzad-Behbahani, A ;

Klapper, PE ;

Vallely, PJ ;

Cleator, GM .

ARCHIVES OF DISEASE IN CHILDHOOD, 2003, 88 (02) :174-175

[9] Thrombotic microangiopathy (TMA) and stroke due to human herpesvirus-6 (HHV-6) reactivation in an adult receiving high-dose melphalan with autologous peripheral stem cell transplantation [J].

Belford, A ;

Myles, O ;

Magill, A ;

Wang, J ;

Myhand, RC ;

Waselenko, JK .

AMERICAN JOURNAL OF HEMATOLOGY, 2004, 76 (02) :156-162

[10] Frequency and Significance of HIV Infection among Patients Diagnosed with Thrombotic Thrombocytopenic Purpura [J].

Benjamin, Melody ;

Terrell, Deirdra R. ;

Vesely, Sara K. ;

Voskuhl, Gene W. ;

Dezube, Bruce J. ;

Hovinga, Johanna A. Kremer ;

Laemmle, Bernhard ;

George, James N. .

CLINICAL INFECTIOUS DISEASES, 2009, 48 (08) :1129-1137

← 1 2 3 4 5 →