Preparation and complex characterization of silica holmium sol-gel monoliths

被引：4

作者：

Cacaina, D. ^{[1
]}

Areva, S. ^{[1
,2
]}

Laaksonen, H. ^{[1
,2
]}

Simon, S. ^{[3
]}

Ylanen, H. ^{[1
,2
]}

机构：

[1] Univ Turku, Turku Biomat Ctr, SF-20500 Turku, Finland

[2] Tampere Univ Technol, Dept Biomed Engn, FIN-33101 Tampere, Finland

[3] Univ Babes Bolyai, Fac Phys, Cluj Napoca 400084, Romania

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2011年 / 22卷 / 01期

关键词：

POLY(L-LACTIC ACID) MICROSPHERES; INTERNAL RADIATION-THERAPY; IN-VITRO; STATE; GLASS; YTTRIUM; STABILITY; COATINGS; BEHAVIOR; SIO2;

D O I：

10.1007/s10856-010-4186-2

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Amorphous, sol-gel derived SiO2 are known to biocompatible and bioresorbable materials. Biodegradable and inert materials containing radioactive isotopes have potential application as delivery vehicles of the beta radiation to the cancer tumors inside the body. Incorporation of holmium in the sol-gel derived SiO2 could lead to the formation of a biodegradable material which could be used as carrier biomaterial for the radiation of radioactive holmium to the various cancer sites. The homogeneity of the prepared sol-gel silica holmium monoliths was investigated by Back Scattered Electron Imaging of Scanning Electron Microscope equipped with Energy Dispersive X-ray Analysis, X-ray Induced Photoelectron Spectroscopy and Nuclear Magnetic Resonance Spectroscopy. The biodegradation of the monoliths was investigated in Simulated Body Fluid and TRIS (Trizma pre-set Crystals) solution. The results show that by suitable tailoring of the sol-gel processing parameters holmium can be homogeneously incorporated in the silica matrix with a controlled biodegradation rate.

引用

页码：29 / 40

页数：12

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