Raman spectroscopic study of human tissues

Raman spectroscopy has been applied to the investigation of human thyroid, lung, oviduct, ovarian, cervical, and uterine tissues. Thyroid and uterine tissues exhibit more Raman bands than the other tissues in the range from 500 to 3 500 cm(-1) with 514.5 mn excitation, while lung and cervical tissue do not show any bands. In the range of 600-1800 cm(-1), uterine and ovarian tissues show only the Raman features of carotenoids near 1 004, 1 158, and 1 520 cm(-1). Remarkable differences between normal and follicular carcinoma samples of thyroid were observed by the absence of characteristic bands at 1585 and 1634 cm-' in the latter. The spectral intensity of lung cancerous sample is much lower than that of normal sample, by which normal and malignant samples can be discriminated: The results indicate that Raman spectroscopic technique will play an important rule in clinical diagnosing.