Anticoagulation in COVID-19: current concepts and controversies

被引：52

作者：

Chandra, Atanu ^{[1
]}

Chakraborty, Uddalak ^{[2
]}

Ghosh, Shrestha ^{[1
]}

Dasgupta, Sugata ^{[3
]}

机构：

[1] RG Kar Med Coll & Hosp, Internal Med, Kolkata, India

[2] Bangur Inst Neurol, Inst Postgrad Med Educ & Res, Neurol, Kolkata, W Bengal, India

[3] RG Kar Med Coll & Hosp, Crit Care Med, Kolkata, W Bengal, India

来源：

POSTGRADUATE MEDICAL JOURNAL | 2022年 / 98卷 / 1159期

关键词：

COVID-19; anticoagulation; internal medicine; thromboembolism; SARS-COV-2; MANAGEMENT; RISK;

D O I：

10.1136/postgradmedj-2021-139923

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rising incidence of thromboembolism secondary to COVID-19 has become a global concern, with several surveys reporting increased mortality rates. Thrombogenic potential of the SARS-CoV-2 virus has been hypothesised to originate from its ability to produce an exaggerated inflammatory response leading to endothelial dysfunction. Anticoagulants have remained the primary modality of treatment of thromboembolism for decades. However, there is no universal consensus regarding the timing, dosage and duration of anticoagulation in COVID-19 as well as need for postdischarge prophylaxis. This article seeks to review the present guidelines and recommendations as well as the ongoing trials on use of anticoagulants in COVID-19, identify discrepancies between all these, and provide a comprehensive strategy regarding usage of these drugs in the current pandemic.

引用

页码：395 / 402

页数：8

共 61 条

[1] Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 [J].

Ackermann, Maximilian ;

Verleden, Stijn E. ;

Kuehnel, Mark ;

Haverich, Axel ;

Welte, Tobias ;

Laenger, Florian ;

Vanstapel, Arno ;

Werlein, Christopher ;

Stark, Helge ;

Tzankov, Alexandar ;

Li, William W. ;

Li, Vincent W. ;

Mentzer, Steven J. ;

Jonigk, Danny .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (02) :120-128

[2] Heparin induced thrombocytopenia: diagnosis and management update [J].

Ahmed, I. ;

Majeed, A. ;

Powell, R. .

POSTGRADUATE MEDICAL JOURNAL, 2007, 83 (983) :575-582

[3] Thrombosis in Coronavirus disease 2019 (COVID-19) through the prism of Virchow's triad [J].

Ahmed, Sakir ;

Zimba, Olena ;

Gasparyan, Armen Yuri .

CLINICAL RHEUMATOLOGY, 2020, 39 (09) :2529-2543

[4] Covid-19 and Kidney Transplantation [J].

Akalin, Enver ;

Azzi, Yorg ;

Bartash, Rachel ;

Seethamraju, Harish ;

Parides, Michael ;

Hemmige, Vagish ;

Ross, Michael ;

Forest, Stefanie ;

Goldstein, Yitz D. ;

Ajaimy, Maria ;

Liriano-Ward, Luz ;

Pynadath, Cindy ;

Loarte-Campos, Pablo ;

Nandigam, Purna B. ;

Graham, Jay ;

Le, Marie ;

Rocca, Juan ;

Kinkhabwala, Milan .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (25) :2475-2477

[5] A single center observational study lb Check of the clinical characteristics and short-term outcome of 20 kidney transplant patients admitted for SARS-CoV2 pneumonia [J].

Alberici, Federico ;

Delbarba, Elisa ;

Manenti, Chiara ;

Econimo, Laura ;

Valerio, Francesca ;

Pola, Alessandra ;

Maffei, Camilla ;

Possenti, Stefano ;

Zambetti, Nicole ;

Moscato, Marianna ;

Venturini, Margherita ;

Affatato, Stefania ;

Gaggiotti, Mario ;

Bossini, Nicola ;

Scolari, Francesco .

KIDNEY INTERNATIONAL, 2020, 97 (06) :1083-1088

[6]

Alquwaizani M, 2013, CURR EMERG HOSP ME R, V1, P83, DOI 10.1007/s40138-013-0014-6

[7]

American Society of Hematology, COVID 19 COAG

[8] Incidence of acute pulmonary embolism, related comorbidities and survival; analysis of a Swedish national cohort [J].

Andersson, Therese ;

Soderberg, Stefan .

BMC CARDIOVASCULAR DISORDERS, 2017, 17

[9] Thromboembolism and anticoagulant therapy during the COVID-19 pandemic: interim clinical guidance from the anticoagulation forum [J].

Barnes, Geoffrey D. ;

Burnett, Allison ;

Allen, Arthur ;

Blumenstein, Marilyn ;

Clark, Nathan P. ;

Cuker, Adam ;

Dager, William E. ;

Deitelzweig, Steven B. ;

Ellsworth, Stacy ;

Garcia, David ;

Kaatz, Scott ;

Minichiello, Tracy .

JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2020, 50 (01) :72-81

[10] Acute pulmonary embolism: mortality prediction by the 2014 European Society of Cardiology risk stratification model [J].

Becattini, Cecilia ;

Agnelli, Giancarlo ;

Lankeit, Mareike ;

Masotti, Luca ;

Pruszczyk, Piotr ;

Casazza, Franco ;

Vanni, Simone ;

Nitti, Cinzia ;

Kamphuisen, Pieter ;

Vedovati, Maria Cristina ;

De Natale, Maria Grazia ;

Konstantinides, Stavros .

EUROPEAN RESPIRATORY JOURNAL, 2016, 48 (03) :780-786

← 1 2 3 4 5 6 7 →