A mathematical model of cellular immune response to leukemia

被引：19
作者：
Kolev, M [1 ]
机构：
[1] Univ Warmia & Mazury, Dept Math & Informat Technol, PL-10561 Olsztyn, Poland
来源：
MATHEMATICAL AND COMPUTER MODELLING | 2005年 / 41卷 / 10期
关键词：
leukemia; integro-differential equations; nonlinear dynamics; dendritic cells; vaccination;
D O I：
10.1016/j.mcm.2005.05.003
中图分类号：
TP39 [计算机的应用];
学科分类号：
081203 ; 0835 ;
摘要：
The cell-mediated immune response is a very important part of the defence mechanism against cancer. In this paper, we present a model of the cellular immune response to leukemia. The model is developed with statistical methods analogous to those of kinetic theory. The cells of the interacting populations are characterized by a microscopic functional state variable. The development of the concept of inner functional state is considered. A new possibility for definition of the activation state, suitable for experimental evaluation, for three particular cell populations is proposed. The presented simulations are related to the modelling of three types of vaccinations. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1071 / 1081
页数：11
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