Glucose Metabolism in Cancer: The Warburg Effect and Beyond

被引:136
作者
Bose, Sminu [1 ]
Zhang, Cissy [2 ,3 ]
Le, Anne [4 ,5 ]
机构
[1] Columbia Univ, Dept Med, Med Ctr, Div Hematol & Oncol, New York, NY USA
[2] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Dept Biol, Krieger Sch Arts & Sci, Baltimore, MD 21218 USA
[4] Johns Hopkins Univ, Sch Med, Dept Pathol & Oncol, Baltimore, MD 21218 USA
[5] Johns Hopkins Univ, Whiting Sch Engn, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA
来源
HETEROGENEITY OF CANCER METABOLISM, 2ND EDITION | 2021年 / 1311卷
关键词
Glucose metabolism; Warburg effect; Glycogenolysis; Gluconeogenesis; Cancer metabolism; PHASE-II TRIAL; LACTATE-DEHYDROGENASE; GLYCOLYTIC FLUX; GLYCOGEN; INHIBITION; HYPOXIA; CELLS; FLAVOPIRIDOL; EXPRESSION; THERAPY;
D O I
10.1007/978-3-030-65768-0_1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:3 / 15
页数:13
相关论文
共 87 条
[1]   Glycogen synthase kinase 3β as a potential therapeutic target in synovial sarcoma and fibrosarcoma [J].
Abe, Kensaku ;
Yamamoto, Norio ;
Domoto, Takahiro ;
Bolidong, Dilireba ;
Hayashi, Katsuhiro ;
Takeuchi, Akihiko ;
Miwa, Shinji ;
Igarashi, Kentaro ;
Inatani, Hiroyuki ;
Aoki, Yu ;
Higuchi, Takashi ;
Taniguchi, Yuta ;
Yonezawa, Hirotaka ;
Araki, Yoshihiro ;
Aiba, Hisaki ;
Minamoto, Toshinari ;
Tsuchiya, Hiroyuki .
CANCER SCIENCE, 2020, 111 (02) :429-440
[2]   Phase II study of flavopiridol in patients with advanced colorectal cancer [J].
Aklilu, M ;
Kindler, HL ;
Donehower, RC ;
Mani, S ;
Vokes, EE .
ANNALS OF ONCOLOGY, 2003, 14 (08) :1270-1273
[3]   GLUT1 as a therapeutic target in hepatocellular carcinoma [J].
Amann, Thomas ;
Hellerbrand, Claus .
EXPERT OPINION ON THERAPEUTIC TARGETS, 2009, 13 (12) :1411-1427
[4]   Different Tumor Microenvironments Lead to Different Metabolic Phenotypes [J].
Antonio, Marjorie Justine ;
Zhang, Cissy ;
Le, Anne .
HETEROGENEITY OF CANCER METABOLISM, 2ND EDITION, 2021, 1311 :137-147
[5]   Potential therapeutic effect of targeting glycogen synthase kinase 3β in esophageal squamous cell carcinoma [J].
Bolidong, Dilireba ;
Domoto, Takahiro ;
Uehara, Masahiro ;
Sabit, Hemragul ;
Okumura, Tomoyuki ;
Endo, Yoshio ;
Nakada, Mitsutoshi ;
Ninomiya, Itasu ;
Miyashita, Tomoharu ;
Wong, Richard W. ;
Minamoto, Toshinari .
SCIENTIFIC REPORTS, 2020, 10 (01)
[6]   The Intricate Metabolism of Pancreatic Cancers [J].
Camelo, Felipe ;
Le, Anne .
HETEROGENEITY OF CANCER METABOLISM, 2ND EDITION, 2021, 1311 :77-88
[7]   Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality [J].
Chan, Denise A. ;
Sutphin, Patrick D. ;
Nguyen, Phuong ;
Turcotte, Sandra ;
Lai, Edwin W. ;
Banh, Alice ;
Reynolds, Gloria E. ;
Chi, Jen-Tsan ;
Wu, Jason ;
Solow-Cordero, David E. ;
Bonnet, Muriel ;
Flanagan, Jack U. ;
Bouley, Donna M. ;
Graves, Edward E. ;
Denny, William A. ;
Hay, Michael P. ;
Giaccia, Amato J. .
SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (94)
[8]   Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer [J].
Chapiro, Julius ;
Sur, Surojit ;
Savic, Lynn Jeanette ;
Ganapathy-Kanniappan, Shanmugasundaram ;
Reyes, Juvenal ;
Duran, Rafael ;
Thiruganasambandam, Sivarajan Chettiar ;
Moats, Cassandra Rae ;
Lin, MingDe ;
Luo, Weibo ;
Tran, Phuoc T. ;
Herman, Joseph M. ;
Semenza, Gregg L. ;
Ewald, Andrew J. ;
Vogelstein, Bert ;
Geschwind, Jean-Francois .
CLINICAL CANCER RESEARCH, 2014, 20 (24) :6406-6417
[9]   Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress [J].
Cheng, Kwai Wa ;
Agarwal, Roshan ;
Mitra, Shreya ;
Lee, Ju-Seog ;
Carey, Mark ;
Gray, Joe W. ;
Mills, Gordon B. .
EMBO MOLECULAR MEDICINE, 2012, 4 (02) :125-141
[10]   The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth [J].
Christofk, Heather R. ;
Vander Heiden, Matthew G. ;
Harris, Marian H. ;
Ramanathan, Arvind ;
Gerszten, Robert E. ;
Wei, Ru ;
Fleming, Mark D. ;
Schreiber, Stuart L. ;
Cantley, Lewis C. .
NATURE, 2008, 452 (7184) :230-U74