Toward the total synthesis of disorazole A1:: Asymmetric synthesis of the masked northern half

被引：15

作者：

Hartung, IV ^{[1
]}

Eggert, U ^{[1
]}

Haustedt, LO ^{[1
]}

Niess, B ^{[1
]}

Schäfer, PM ^{[1
]}

Hoffmann, HMR ^{[1
]}

机构：

[1] Leibniz Univ Hannover, Dept Organ Chem, D-30167 Hannover, Germany

来源：

SYNTHESIS-STUTTGART | 2003年 / Georg Thieme Verlag卷 / 12期

关键词：

total synthesis; cell cycle modulation; polyketides; oxazoles; Wittig reactions;

D O I：

10.1055/s-2003-41033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereoselective synthesis of the masked northern half of the antimitotic natural product disorazole A, is described involving as key step a Z-selective Wittig olefination of a Cl-Cl I epoxy aldehyde with a C12-C19 phosphonium iodide.

引用

页码：1844 / 1850

页数：7

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