Nevirapine-selected mutations Y181I/C of HIV-1 reverse transcriptase confer cross-resistance to stavudine

被引：18

作者：

Baldanti, F ^{[1
]}

Paolucci, S

Maga, G

Labo, N

Hübscher, U

Skoblov, AY

Victorova, L

Spadari, S

Minoli, L

Gerna, G

机构：

[1] IRCCS, Policlin San Matteo, Serv Virol, Pavia, Italy

[2] CNR, Ist Genet Mol, Pavia, Italy

[3] Univ Zurich, Inst Vet Biochem & Mol Biol, Zurich, Switzerland

[4] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow, Russia

[5] Univ Pavia, Ist Clin Malattie Infett, Pavia, Italy

来源：

AIDS | 2003年 / 17卷 / 10期

关键词：

D O I：

10.1097/00002030-200307040-00021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Stavudine administration did not increase the frequency of Y181I/C reverse transcriptase (RT) mutations in non-nucleoside reverse transcriptase inhibitor (NNRTI)-treated patients. However, recombinant Y181C HIV-1 showed reduced stavudine susceptibility with respect to both recombinant wild-type and K103N HIV-1 strains. In addition, recombinant Y181I RT enzyme showed reduced susceptibility to stavudine with respect to both wild-type and K103N RT. A previously unnoticed role of Y181I/C RT changes selected by nevirapine or other NNRTI in determining stavudine resistance is documented.

引用

页码：1568 / 1570

页数：3

共 6 条

[1] Human immunodeficiency virus type 1 drug susceptibility determination by using recombinant viruses generated from patient sera tested in a cell-killing assay
Boucher, CAB
Keulen, W
vanBommel, T
Nijhuis, M
DeJong, D
DeJong, MD
Schipper, P
Back, NKT
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (10) : 2404 - 2409
[2] NOVEL MUTATION (V75T) IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE CONFERS RESISTANCE TO 2',3'-DIDEHYDRO-2',3'-DIDEOXYTHYMIDINE IN CELL-CULTURE
LACEY, SF
LARDER, BA
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (06) : 1428 - 1432
[3] A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance
Larder, BA
Bloor, S
Kemp, SD
Hertogs, K
Desmet, RL
Miller, V
Sturmer, M
Staszewski, S
Ren, J
Stammers, DK
Stuart, DI
Pauwels, R
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (08) : 1961 - 1967
[4] Resistance to Nevirapine of HIV-1 reverse transcriptase mutants: Loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions
Maga, G
Amacker, M
Ruel, N
Hubscher, U
Spadari, S
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1997, 274 (05) : 738 - 747
[5] Combinations against combinations: Associations of anti-HIV 1 reverse transcriptase drugs challenged by constellations of drug resistance mutations
Maga, G
Spadari, S
[J]. CURRENT DRUG METABOLISM, 2002, 3 (01) : 73 - 95
[6] CHIMERIC HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TYPE-2 REVERSE TRANSCRIPTASES DISPLAY REVERSED SENSITIVITY TO NONNUCLEOSIDE ANALOG INHIBITORS
SHIH, CK
ROSE, JM
HANSEN, GL
WU, JC
BACOLLA, A
GRIFFIN, JA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (21) : 9878 - 9882

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