Successful Systemic and Topical Treatment of Mycobacterium abscessus Otomastoiditis

被引：10

作者：

van Wijk, Floor ^{[1
,2
]}

Waterval, Jerome ^{[3
,4
]}

van Aerde, Koen ^{[1
]}

Henriet, Stefanie S., V ^{[1
]}

Meijer, F. J. Anton ^{[5
]}

Borra, Lennaert C. ^{[6
]}

Aarnoutse, Rob E. ^{[6
]}

van Ingen, Jakko ^{[7
]}

机构：

[1] Radboud Univ Nijmegen, Amalias Children Hosp, Med Ctr, Dept Pediat, Nijmegen, Netherlands

[2] Univ Hosp Brussels, Dept Pediat, Brussels, Belgium

[3] Radboud Univ Nijmegen, Med Ctr, Dept Otorhinolaryngol, Nijmegen, Netherlands

[4] Maastricht Univ, Med Ctr, Dept Otorhinolaryngol, Maastricht, Netherlands

[5] Radboud Univ Nijmegen, Med Ctr, Dept Radiol & Nucl Med, Nijmegen, Netherlands

[6] Radboud Univ Nijmegen, Med Ctr, Dept Pharm, Nijmegen, Netherlands

[7] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, Nijmegen, Netherlands

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2020年 / 64卷 / 01期

关键词：

Mycobacterium abscessus; mastoiditis; otitis; tigecycline; clofazimine; Mycobacterium; experimental therapeutics; otitis media; pediatric drug therapy; CLOFAZIMINE; TIGECYCLINE; AMIKACIN;

D O I：

10.1128/AAC.01203-19

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mycobacterium abscessus is an extensively drug-resistant opportunistic pathogen that can cause chronic otomastoiditis. There are no evidence-based treatment regimens for this severe infection. We treated four children with M. abscessus otomastoiditis with a structured regimen of topical imipenem and tigecycline, intravenous imipenem and tigecycline, and oral clofazimine and azithromycin and adjunctive surgery. This structured approach led to cure, with 1 year of follow-up after treatment. Adverse events were frequent, mostly caused by tigecycline.

引用

页数：5

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