Lignans and Their Derivatives from Plants as Antivirals

被引：127
作者：
Cui, Qinghua [1 ,2 ,3 ]
Du, Ruikun [1 ,2 ,3 ]
Liu, Miaomiao [1 ]
Rong, Lijun [4 ]
机构：
[1] Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China
[2] Shandong Univ Tradit Chinese Med, Qingdao Acad Chinese Med Sci, Qingdao 266122, Peoples R China
[3] Shandong Univ Tradit Chinese Med, Res Ctr, Jinan 250355, Peoples R China
[4] Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL 60612 USA
来源：
MOLECULES | 2020年 / 25卷 / 01期
关键词：
lignans; antivirals; mechanism; drug development; V-ATPASE INHIBITOR; HEPATITIS-B; NORDIHYDROGUAIARETIC ACID; INFLUENZA-A; IN-VITRO; SCHISANDRA-CHINENSIS; VIRUS; DIPHYLLIN; ROOT; TRANSCRIPTION;
D O I：
10.3390/molecules25010183
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lignans are widely produced by various plant species; they are a class of natural products that share structural similarity. They usually contain a core scaffold that is formed by two or more phenylpropanoid units. Lignans possess diverse pharmacological properties, including their antiviral activities that have been reported in recent years. This review discusses the distribution of lignans in nature according to their structural classification, and it provides a comprehensive summary of their antiviral activities. Among them, two types of antiviral lignans-podophyllotoxin and bicyclol, which are used to treat venereal warts and chronic hepatitis B (CHB) in clinical, serve as examples of using lignans for antivirals-are discussed in some detail. Prospects of lignans in antiviral drug discovery are also discussed.
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页数：17
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