Overexpression of hUMP1/POMP proteasome accessory protein enhances proteasome-mediated antioxidant defence

被引：47

作者：

Chondrogianni, Niki ^{[1
]}

Gonos, Efstathios S. ^{[1
]}

机构：

[1] Natl Hellen Res Fdn, Inst Biol Res & Biotechnol, GR-11635 Athens, Greece

来源：

EXPERIMENTAL GERONTOLOGY | 2007年 / 42卷 / 09期

关键词：

hUMP1/POMP; proteasome assembly; oxidative stress; survival;

D O I：

10.1016/j.exger.2007.01.012

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The proteasome is the major cellular proteolytic machinery. It is involved in the regulation of various pathways via the selective degradation of either short-lived normal proteins or damaged proteins permitting the cellular detoxification. Proteasome has impaired function during several biological processes, including aging and diseases; however, it can be activated through overexpression Of beta(5)- or beta(1)-subunits, resulting to enhanced survival and extended lifespan. In the current study, we have investigated proteasomal up-regulation via overexpression of hUMP1/POMP protein, the known accessory factor for proteasome assembly in humans. hUMP1/POMP overexpressing fibroblasts have increased levels of functional proteasome and enhanced capacity to cope better and faster with various oxidative stressors. These data highlight hUMP1/POMP role in proteasome assembly and further strengthen the prospect of genetic manipulation of the proteasomal system. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：899 / 903

页数：5

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