Modifications of the Innate Immune System in Atopic Dermatitis

被引：35

作者：

Maintz, Laura ^{[1
]}

Novak, Natalija ^{[1
]}

机构：

[1] Univ Bonn, Dept Dermatol & Allergy, DE-53127 Bonn, Germany

来源：

JOURNAL OF INNATE IMMUNITY | 2011年 / 3卷 / 02期

关键词：

Allergy; Antimicrobial peptides; Pathogen-associated molecular patterns; Toll-like receptor; PLASMACYTOID DENDRITIC CELLS; TOLL-LIKE RECEPTOR-2; STAPHYLOCOCCUS-AUREUS; ANTIMICROBIAL PEPTIDES; PROMOTER POLYMORPHISM; SKIN INFLAMMATION; BETA-DEFENSINS; TH2; CYTOKINES; RISK-FACTORS; T-CELLS;

D O I：

10.1159/000323963

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Atopic dermatitis (AD) is a frequent chronic inflammatory skin disease which is often complicated by recurrent microbial superinfections. Genetically based modifications which might have an impact on the innate immune system, such as impairment of the skin barrier, modifications of pattern recognition receptors, deficiency of antimicrobial peptides, antiviral natural killer cells and plasmacytoid dendritic cells, facilitate the entry of allergens and infectious microbes into the skin, where they encounter immunocompetent cells. The micromilieu in the skin of AD patients further potentiates dysfunctions of the innate immune system, leading to a vicious circle promoting the disease. This article provides an overview of modifications of the innate immune system in AD. Introduction Copyright (c) 2011 S. Karger AG, Basel

引用

页码：131 / 141

页数：11

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