One-pot synthesis of 2-isopropyl-3-benzyl-1,3-thiazolidin-4-ones and 2-phenyl-3-isobutyl-1,3-thiazolidin-4-ones from valine, arenealdehydes and mercaptoacetic acid

被引：36

作者：

Cunico, Wilson ^{[1
]}

Gorries, Claudia R. B. ^{[1
]}

Ferreira, Maria de Lourdes G. ^{[1
]}

Capri, Liliane R. ^{[1
]}

Soares, Marcio ^{[1
]}

Wardell, Solange M. S. V. ^{[1
]}

机构：

[1] Inst Tecnol Farmacos, FioCruz Fundacao Oswaldo Cruz, BR-21041250 Rio De Janeiro, Brazil

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 35期

基金：

英国工程与自然科学研究理事会;

关键词：

4-thiazolidinone; heterocycles; valine; one-pot reaction; cycloaddition;

D O I：

10.1016/j.tetlet.2007.06.101

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A three-component one-pot synthesis of 2-isopropyl-3-benzyl-1,3-thiazolidin-4-ones and 2-phenyl-3-isobutyl-1,3-thiazolidin-4-ones front valine, arenealdehydes and mercaptoacetic acid with good yields is reported. Characterization of products was generally achieved by NMR techniques and specifically for 2-isopropyl-3-(4-nitrobenzyl)-1,3-thiazolidin-4-one by X-ray crystallography. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：6217 / 6220

页数：4

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