Metal-Ion-Activated DNAzymes Used for Regulation of Telomerase Activity in Living Cells

被引：18

作者：

Wang, Jiasi ^{[1
,2
,3
]}

Qin, Hongshuang ^{[1
,2
]}

Wang, Faming ^{[1
,2
,3
]}

Ren, Jinsong ^{[1
,2
]}

Qu, Xiaogang ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Biol Chem Lab, Changchun 130022, Jilin, Peoples R China

[2] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100039, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2017年 / 23卷 / 47期

关键词：

cell cycle; cell migration; DNAzyme; metal ions; telomerase; REVERSE-TRANSCRIPTASE; CATALYTIC SUBUNIT; HUMAN-DISEASE; GENE; RNA; CANCER; CLEAVAGE; HTERT; MICE; DNA;

D O I：

10.1002/chem.201702236

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Telomerase is a key regulator in cell metabolism, tissue renewal, and organismal lifespan. Here we develop a simple strategy to modulate cellular telomerase activity, and further control cell fate based on Mg2+- and Zn2+-activated DNAzymes in living cells. Through modulation of telomerase activity, we can regulate cell behavior, including cell migration, cell differentiation, cell senescence, and cell cycle. Our work provides a new way to modulate telomerase activity in living cells by using DNAzymes.

引用

页码：11226 / 11229

页数：4

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