Metal-Ion-Activated DNAzymes Used for Regulation of Telomerase Activity in Living Cells

被引：18
作者：
Wang, Jiasi [1 ,2 ,3 ]
Qin, Hongshuang [1 ,2 ]
Wang, Faming [1 ,2 ,3 ]
Ren, Jinsong [1 ,2 ]
Qu, Xiaogang [1 ,2 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, Biol Chem Lab, Changchun 130022, Jilin, Peoples R China
[2] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Jilin, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100039, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2017年 / 23卷 / 47期
关键词：
cell cycle; cell migration; DNAzyme; metal ions; telomerase; REVERSE-TRANSCRIPTASE; CATALYTIC SUBUNIT; HUMAN-DISEASE; GENE; RNA; CANCER; CLEAVAGE; HTERT; MICE; DNA;
D O I：
10.1002/chem.201702236
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Telomerase is a key regulator in cell metabolism, tissue renewal, and organismal lifespan. Here we develop a simple strategy to modulate cellular telomerase activity, and further control cell fate based on Mg2+- and Zn2+-activated DNAzymes in living cells. Through modulation of telomerase activity, we can regulate cell behavior, including cell migration, cell differentiation, cell senescence, and cell cycle. Our work provides a new way to modulate telomerase activity in living cells by using DNAzymes.
引用
收藏
页码：11226 / 11229
页数：4
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