Identification of immune-activating metabolite for enhancing T cell therapy of cancer

被引:3
作者
Cong, Boyi [1 ]
Cui, Zenghui [1 ]
Cao, Xuetao [1 ,2 ]
机构
[1] Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China
[2] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Immunol, Ctr Immunotherapy, Beijing 100005, Peoples R China
基金
中国国家自然科学基金;
关键词
GLUTAMINE;
D O I
10.1002/cac2.12177
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
[No abstract available]
引用
收藏
页码:535 / 537
页数:3
相关论文
共 14 条
[1]   Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal [J].
Baumann, Tobias ;
Dunkel, Andreas ;
Schmid, Christian ;
Schmitt, Sabine ;
Hiltensperger, Michael ;
Lohr, Kerstin ;
Laketa, Vibor ;
Donakonda, Sainitin ;
Ahting, Uwe ;
Lorenz-Depiereux, Bettina ;
Heil, Jan E. ;
Schredelseker, Johann ;
Simeoni, Luca ;
Fecher, Caroline ;
Koerber, Nina ;
Bauer, Tanja ;
Hueser, Norbert ;
Hartmann, Daniel ;
Laschinger, Melanie ;
Eyerich, Kilian ;
Eyerich, Stefanie ;
Anton, Martina ;
Streeter, Matthew ;
Wang, Tina ;
Schraven, Burkhart ;
Spiegel, David ;
Assaad, Farhah ;
Misgeld, Thomas ;
Zischka, Hans ;
Murray, Peter J. ;
Heine, Annkristin ;
Heikenwaelder, Mathias ;
Korn, Thomas ;
Dawid, Corinna ;
Hofmann, Thomas ;
Knolle, Percy A. ;
Hoechst, Bastian .
NATURE IMMUNOLOGY, 2020, 21 (05) :555-+
[2]   p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival [J].
Deng, Longfei ;
Yao, Pengbo ;
Li, Le ;
Ji, Fansen ;
Zhao, Shuang ;
Xu, Chang ;
Lan, Xun ;
Jiang, Peng .
NATURE COMMUNICATIONS, 2020, 11 (01)
[3]   Fuel feeds function: Energy metabolism and the T-cell response [J].
Fox, CJ ;
Hammerman, PS ;
Thompson, CB .
NATURE REVIEWS IMMUNOLOGY, 2005, 5 (11) :844-852
[4]   Metabolic Regulation of T Lymphocytes [J].
MacIver, Nancie J. ;
Michalek, Ryan D. ;
Rathmell, Jeffrey C. .
ANNUAL REVIEW OF IMMUNOLOGY, VOL 31, 2013, 31 :259-283
[5]   Glutamine and asparagine activate mTORC1 independently of Rag GTPases [J].
Meng, Delong ;
Yang, Qianmei ;
Wang, Huanyu ;
Melick, Chase H. ;
Navlani, Rishika ;
Frank, Anderson R. ;
Jewell, Jenna L. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 295 (10) :2890-2899
[6]   Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation [J].
Nakaya, Mako ;
Xiao, Yichuan ;
Zhou, Xiaofei ;
Chang, Jae-Hoon ;
Chang, Mikyoung ;
Cheng, Xuhong ;
Blonska, Marzenna ;
Lin, Xin ;
Sun, Shao-Cong .
IMMUNITY, 2014, 40 (05) :692-705
[7]   Cell-programmed nutrient partitioning in the tumour microenvironment [J].
Reinfeld, Bradley, I ;
Madden, Matthew Z. ;
Wolf, Melissa M. ;
Chytil, Anna ;
Bader, Jackie E. ;
Patterson, Andrew R. ;
Sugiura, Ayaka ;
Cohen, Allison S. ;
Ali, Ahmed ;
Do, Brian T. ;
Muir, Alexander ;
Lewis, Caroline A. ;
Hongo, Rachel A. ;
Young, Kirsten L. ;
Brown, Rachel E. ;
Todd, Vera M. ;
Huffstater, Tessa ;
Abraham, Abin ;
O'Neil, Richard T. ;
Wilson, Matthew H. ;
Xin, Fuxue ;
Tantawy, M. Noor ;
Merryman, W. David ;
Johnson, Rachelle W. ;
Williams, Christopher S. ;
Mason, Emily F. ;
Mason, Frank M. ;
Beckermann, Katherine E. ;
Vander Heiden, Matthew G. ;
Manning, H. Charles ;
Rathmell, Jeffrey C. ;
Rathmell, W. Kimryn .
NATURE, 2021, 593 (7858) :282-+
[8]   Immune precision medicine for cancer: a novel insight based on the efficiency of immune effector cells [J].
Rossi, Jean-Francois ;
Ceballos, Patrice ;
Lu, Zhao-Yang .
CANCER COMMUNICATIONS, 2019, 39
[9]   Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb [J].
Shi, Hao ;
Chapman, Nicole M. ;
Wen, Jing ;
Guy, Cliff ;
Long, Lingyun ;
Dhungana, Yogesh ;
Rankin, Sherri ;
Pelletier, Stephane ;
Vogel, Peter ;
Wang, Hong ;
Peng, Junmin ;
Guan, Kun-Liang ;
Chi, Hongbo .
IMMUNITY, 2019, 51 (06) :1012-+
[10]   A guide to cancer immunotherapy: from T cell basic science to clinical practice [J].
Waldman, Alex D. ;
Fritz, Jill M. ;
Lenardo, Michael J. .
NATURE REVIEWS IMMUNOLOGY, 2020, 20 (11) :651-668