Binding and photodissociation of CO in iron(II) complexes for application in positron emission tomography (PET) radiolabelling

被引：16

作者：

Child, Chloe R. ^{[1
,2
]}

Kealey, Steven ^{[2
]}

Jones, Harriet ^{[3
]}

Miller, Philip W. ^{[1
]}

White, Andrew J. P. ^{[1
]}

Gee, Anthony D. ^{[4
]}

Long, Nicholas J. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[2] Hammersmith Hosp, GlaxoSmithKline Clin Imaging Ctr, London W12 0NN, England

[3] Abbey Sch, Reading RG1 5DZ, Berks, England

[4] Kings Coll London, Rayne Inst, St Thomas Hosp, London SE1 7EH, England

来源：

DALTON TRANSACTIONS | 2011年 / 40卷 / 23期

基金：

英国工程与自然科学研究理事会;

关键词：

REACTIVITY; MONOXIDE;

D O I：

10.1039/c0dt01614d

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

(R-DAB)FeI(2) complexes containing bidentate diimide ligands (R-DAB = RN=CH-CH=NR; R = (i)Pr, c-C(6)H(11)) have been investigated for their ability to react with carbon monoxide to form iron(II) dicarbonyl complexes, (R-DAB)FeI(2)(CO)(2). Solution IR spectroscopy revealed two vCO stretches between 2000 and 2040 cm(-1) corresponding to a cis-arrangement of the carbonyl ligands around the iron. Photochemical decarbonylation was achieved by UV irradiation (365 nm), which occurred within 5 min as evidenced by solution IR spectroscopy. (c-C(6)H(11)-DAB)FeI(2) has been characterised by X-ray crystallography. Reactions using (11)C-labelled carbon monoxide were investigated and revealed that both (R-DAB)FeI(2) species were not effective as trapping complexes due to the low concentrations of [(11)C] CO used in these experiments. A Fe(TPP)(THF)(x) (TPP = tetraphenylporphyrin) complex was investigated with unlabelled CO and the monocarbonyl adduct Fe(TPP)(THF) CO was formed in situ as identified by IR spectroscopy (vCO = 1966 cm(-1)) yet was stable to CO loss upon UV irradiation. Carbonylation reactions of in situ-generated Fe(TPP)(THF)(x) using [(11)C] CO revealed that 97% of the [(11)C] CO stream could be trapped in one pass of the gas at room temperature and at atmospheric pressure.

引用

页码：6210 / 6215

页数：6

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