共 36 条
Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions
被引:110
作者:

Knerr, I
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机构: Univ Erlangen Nurnberg, Inst Biochem, D-8520 Erlangen, Germany

Schubert, SW
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机构: Univ Erlangen Nurnberg, Inst Biochem, D-8520 Erlangen, Germany

Wich, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Erlangen Nurnberg, Inst Biochem, D-8520 Erlangen, Germany

Amann, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Erlangen Nurnberg, Inst Biochem, D-8520 Erlangen, Germany

Aigner, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Erlangen Nurnberg, Inst Biochem, D-8520 Erlangen, Germany

Vogler, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Erlangen Nurnberg, Inst Biochem, D-8520 Erlangen, Germany

Jung, R
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h-index: 0
机构: Univ Erlangen Nurnberg, Inst Biochem, D-8520 Erlangen, Germany

Dötsch, J
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h-index: 0
机构: Univ Erlangen Nurnberg, Inst Biochem, D-8520 Erlangen, Germany

Rascher, W
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h-index: 0
机构: Univ Erlangen Nurnberg, Inst Biochem, D-8520 Erlangen, Germany

Hashemolhosseini, S
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机构:
Univ Erlangen Nurnberg, Inst Biochem, D-8520 Erlangen, Germany Univ Erlangen Nurnberg, Inst Biochem, D-8520 Erlangen, Germany
机构:
[1] Univ Erlangen Nurnberg, Inst Biochem, D-8520 Erlangen, Germany
[2] Univ Erlangen Nurnberg, Hosp Children & Adolescents, D-8520 Erlangen, Germany
[3] Univ Erlangen Nurnberg, Dept Pathol, D-8520 Erlangen, Germany
关键词:
Connexin-43;
glial cells missing a;
hypoxia;
syncytin;
syncytiotrophoblast;
D O I:
10.1016/j.febslet.2005.06.029
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Glial cells missing a (GCMa) belongs to a new transcription factor family. Syncytin was shown to be a target gene of GCMa. Here, we demonstrate that the protein kinase A (PKA) pathway acts upstream of GCMa. After transient transfection of BeWo cells with PKA, GCMa transcriptional activity and both GCMa and syncytin transcripts were upregulated. This increase was accompanied by further cellular differentiation. Using normoxic or hypoxic conditions to mimic pathophysiological settings known to diminish trophoblast differentiation, we found that gene repressive effects of oxygen deficiency were compensated by the induction of the PKA pathway. We propose that GCMa-driven syncytin expression is the key mechanism for syncytiotrophoblast formation. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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页码:3991 / 3998
页数:8
相关论文
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