Study of aminoglycoside-nucleic acid interactions by an HPLC method

被引：8
作者：
Constantinou-Kokotou, V
Karikas, G
Kokotos, G [1 ]
机构：
[1] Univ Athens, Dept Chem, Organ Chem Lab, Athens 15771, Greece
[2] Univ Agr, Chem Lab, Athens 11855, Greece
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 08期
关键词：
D O I：
10.1016/S0960-894X(01)00115-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The interactions of a number of aminoglycoside antibiotics with tRNA and DNA were studied by an HPLC method, based on tRNA and DNA peak size exclusion. Among the compounds studied (deoxystreptamine. neamine, neomycin B, kanamycin A, gentamicin A, netilmicin. streptomycin, and the synthetic neamine analogue BKN3), neomycin B and the synthetic analogue of neamine were proved to be the most potent binders, (C) 2001 Elsevier Science Ltd. All rights reserved.
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页码：1015 / 1018
页数：4
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