Is clozapine an (partial) agonist at both dopamine D1 and D2 receptors?

被引：18

作者：

Jackson, DM ^{[1
]}

Wikström, H

Liao, Y

机构：

[1] Astra Arcus AB, Preclin R&D, S-15185 Sodertalje, Sweden

[2] Dalhousie Univ, Dept Pharmacol, Halifax, NS B3H 4H7, Canada

[3] Univ Groningen, RUG, Dept Med Chem, NL-9713 AV Groningen, Netherlands

来源：

PSYCHOPHARMACOLOGY | 1998年 / 138卷 / 02期

关键词：

D O I：

10.1007/s002130050665

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

引用

页码：213 / 214

页数：2

共 8 条

[1] WHY DOES CLOZAPINE STIMULATE THE MOTOR-ACTIVITY OF RESERPINE-PRETREATED RATS WHEN COMBINED WITH A DOPAMINE D-1 RECEPTOR AGONIST [J].

JACKSON, DM ;

MOHELL, N ;

BENGTSSON, A ;

MALMBERG, A .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 282 (1-3) :137-144

[2] Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: Identification of a novel atypical neuroleptic [J].

Liao, Y ;

DeBoer, P ;

Meier, E ;

Wikstrom, H .

JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (25) :4146-4153

[3]

MALMBERG A, 1993, MOL PHARMACOL, V43, P749

[4] Partial agonistic action of clozapine at dopamine D2 receptors in dopamine depleted animals [J].

Ninan, I ;

Kulkarni, SK .

PSYCHOPHARMACOLOGY, 1998, 135 (03) :311-317

[5] ANTAGONISM BY SCH-23390 OF CLOZAPINE-INDUCED HYPOTHERMIA IN THE RAT [J].

SALMI, P ;

KARLSSON, T ;

AHLENIUS, S .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 253 (1-2) :67-73

[6] EVIDENCE FOR SPECIFIC INVOLVEMENT OF DOPAMINE D(1) AND DOPAMINE D(2) RECEPTORS IN THE REGULATION OF BODY-TEMPERATURE IN THE RAT [J].

SALMI, P ;

JIMENEZ, P ;

AHLENIUS, S .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 236 (03) :395-400

[7] Further evidence for clozapine as a dopamine D-1 receptor agonist [J].

Salmi, P ;

Ahlenius, S .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1996, 307 (01) :27-31

[8] The promise of new drugs for schizophrenia treatment [J].

Tamminga, CA .

CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 1997, 42 (03) :265-273

← 1 →